Involvement of mtDNA damage in free fatty acid-induced apoptosis
Abstract
A growing body of evidence indicates that free fatty acids (FFA) can have deleterious effects on beta-cells. It has been suggested that the beta-cell dysfunction and death observed in diabetes may involve exaggerated activation of the inducible form of nitric oxide synthase (iNOS) by FFA, with the resultant generation of excess nitric oxide (NO). However, the cellular targets with which NO interact have not been fully identified. We hypothesized...
Paper Details
Title
Involvement of mtDNA damage in free fatty acid-induced apoptosis
Published Date
Mar 1, 2005
Volume
38
Issue
6
Pages
755 - 762
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