Original paper
General Anesthetics Sensitize the Capsaicin Receptor Transient Receptor Potential V1
Abstract
General anesthetics (GAs) are central nervous system depressants that render patients unresponsive to external stimuli. In contrast, many of these agents are also known to stimulate peripheral sensory nerves, raising the possibility that they may exacerbate tissue inflammation. We have found that pungent GAs excite sensory neurons by directly activating the transient receptor potential (TRP) A1 ion channel. Here, we show that GAs also sensitize...
Paper Details
Title
General Anesthetics Sensitize the Capsaicin Receptor Transient Receptor Potential V1
Published Date
Aug 8, 2008
Journal
Volume
74
Issue
5
Pages
1261 - 1268
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Notes
History