STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.

Volume: 5, Issue: 214
Published: Mar 6, 2012
Abstract
As part of the innate immune response, various pattern recognition receptors, such as Toll-like receptor 3 (TLR3) and TLR4, activate the kinase TBK1, which phosphorylates the transcription factor IRF3, leading to the production of type I interferons (IFNs). Tanaka and Chen used an in vitro reconstitution system to investigate the mechanism by which TBK1-mediated IRF3 activation occurs in response to the presence of cytosolic DNA from viruses or...
Paper Details
Title
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.
Published Date
Mar 6, 2012
Volume
5
Issue
214
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.