β-Adrenergic-AMPK Pathway Phosphorylates Acetyl-CoA Carboxylase in a High-epinephrine Rat Model, SPORTS
Abstract
We established a new animal model called SPORTS (Spontaneously‐Running Tokushima‐Shikoku) rats, which show high‐epinephrine (Epi) levels. Recent reports show that Epi activates adenosine monophosphate (AMP)–activated protein kinase (AMPK) in adipocytes. Acetyl‐CoA carboxylase (ACC) is the rate‐limiting enzyme in fatty acid synthesis, and the enzymatic activity is suppressed when its Ser‐79 is phosphorylated by AMPK. The aim of this study was to...
Paper Details
Title
β-Adrenergic-AMPK Pathway Phosphorylates Acetyl-CoA Carboxylase in a High-epinephrine Rat Model, SPORTS
Published Date
Jan 1, 2010
Journal
Volume
18
Issue
1
Pages
48 - 54
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