Structure and Functional Characterization of a Novel Human Low-Voltage Activated Calcium Channel

: We have isolated and characterized overlapping cDNAs encoding a novel, voltage‐gated Ca 2+ channel α 1 subunit, α 1H , from a human medullary thyroid carcinoma cell line. The α 1H subunit is structurally similar to previously described α 1 subunits. Northern blot analysis indicates that α 1H mRNA is expressed throughout the brain, primarily in the amygdala, caudate nucleus, and putamen, as well as in several nonneuronal tissues, with...