The Structural Basis of Sirtuin Substrate Affinity,
Abstract
Sirtuins comprise a family of enzymes that catalyze the deacetylation of acetyllysine side chains in a reaction that consumes NAD+. Although several crystal structures of sirtuins bound to non-native acetyl peptides have been determined, relatively little about how sirtuins discriminate among different substrates is understood. We have carried out a systematic structural and thermodynamic analysis of several peptides bound to a single sirtuin,...
Paper Details
Title
The Structural Basis of Sirtuin Substrate Affinity,
Published Date
May 28, 2006
Journal
Volume
45
Issue
24
Pages
7511 - 7521
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Notes
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