P1-363: A phase I trial of parenchymal injection of umbilical cord stem cells in Alzheimer's disease

Alzheimer disease (AD) is the most common cause of dementia. However, disease modifying therapies on AD do not yet exist. Preclinical studies suggested that umbilical cord stems might be effective in AD mouse through various mechanisms such as reducing amyloid burden, decreasing inflammation or increasing endogenous neuronogensis. We hypothesized that parenchymal injection of umbilical cord stem cells could reduce amyloid burden measured by...