The membrane transport of flavonoids from Crossostephium chinense across the Caco‐2 monolayer

The permeation and efflux of six polysubstituted flavonoids isolated from Crossostephium chinense , a Chinese traditional and herbal drug for the treatment of diabetes, were investigated using the Caco‐2 cell monolayer. The six flavonoids (selagin, apometzgerin, tricetin‐3′,4′,5′‐trimethylether, quercetagetin‐3,6,7‐trimethylether, hispidulin and quercetagetin) sharing a similar parent skeleton structure with varied substituents in the...