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Isoflavones: effects on cardiovascular risk and functions

Published on May 1, 2004
· DOI :10.1016/S0531-5131(03)01737-0
Paul Nestel1
Estimated H-index: 1
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Abstract
Abstract Isoflavones, plant polyphenols with estrogenic activity, are becoming widely distributed in foods and sold as supplements. Their similarity to estrogens suggests potential cardiovascular benefits. Two major areas, those of lipid lowering and of improved vascular function, will be reviewed. The novel properties of isoflavone metabolites formed in vivo that may confer specific cardiovascular protection are documented. Although lipid lowering is at best modest, effects on vasculature have been more consistent. Arterial compliance, a parameter of the elasticity or distensibility of large arteries is improved by as much as reported for estrogens. Vasodilatory effects of isoflavones or their metabolites on the microcirculation, suppression of adhesion molecules, antioxidant properties and inhibition of experimental atherosclerosis may provide opportunities for pharmacological intervention.
  • References (14)
  • Citations (10)
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References14
Newest
Published on Mar 1, 2004in European Journal of Clinical Nutrition 3.11
Paul John Nestel2
Estimated H-index: 2
(Monash University),
Marja Cehun10
Estimated H-index: 10
(Monash University)
+ 3 AuthorsBarry P. McGrath42
Estimated H-index: 42
(Monash University)
Objective: To determine whether the two major isoflavones in red clover differ in their effect on low-density lipoprotein cholesterol (LDL-C). Design: A randomised, placebo-controlled, double-blind trial; two parallel groups taking one of the two isoflavones within which treatment and placebo were administered in a crossover design. Setting: Free-living volunteers. Subjects: A total of 46 middle-aged men and 34 postmenopausal women. Interventions: Two mixtures of red clover isoflavones enriched ...
Published on Apr 3, 2003in Arteriosclerosis, Thrombosis, and Vascular Biology 6.62
Helena Teede48
Estimated H-index: 48
(Monash University, Clayton campus),
Barry P. McGrath42
Estimated H-index: 42
(Monash University, Clayton campus)
+ 3 AuthorsPaul John Nestel2
Estimated H-index: 2
(Monash University, Clayton campus)
Objective—This study was undertaken to address the vascular effects of isolated isoflavones as potential contributors to their cardioprotective properties, focusing on biochanin and formononetin. Methods and Results—In a randomized, double-blind trial, 80 healthy subjects, 46 men and 34 women, 45 to 75 years of age, received isoflavones enriched in either biochanin or formononetin (precursors of genistein and daidzein; 80 mg/d) crossed over randomly with placebo in two 6-week periods. The end po...
Published on Nov 1, 2002in Arteriosclerosis, Thrombosis, and Vascular Biology 6.62
Alice H. Lichtenstein79
Estimated H-index: 79
,
Susan M. Jalbert12
Estimated H-index: 12
+ 4 AuthorsLynne M. Ausman37
Estimated H-index: 37
Objective— The objective of this study was to assess the independent effect of soy relative to common sources of animal protein and soy-derived isoflavones on blood lipids. Methods and Results— Forty-two subjects with LDL cholesterol levels ≥3.36 mmol/L were fed each of four diets in randomized order for 6 weeks per phase. Diets contained a minimum of 25 g animal protein or isolated soy protein/4.2 MJ, with each containing trace amounts or 50 mg of isoflavones/4.2 MJ. Soy protein had a modest ef...
Published on Aug 1, 2002in Atherosclerosis 4.25
Francesco Squadrito63
Estimated H-index: 63
(UNIME: University of Messina),
Domenica Altavilla51
Estimated H-index: 51
(UNIME: University of Messina)
+ 8 AuthorsAchille P. Caputi66
Estimated H-index: 66
(UNIME: University of Messina)
Abstract The phytoestrogen genistein improves endothelial dysfunction in ovariectomized rats through a nitric oxide-dependent mechanism. We investigated whether genistein alters the balance between the nitric oxide products and endothelin-1 and influences endothelium-dependent vasodilation in postmenopausal women. Sixty healthy postmenopausal women were enrolled in the study. A double-blind, placebo controlled, randomized design was employed. After a 4-week stabilization on a standard fat-reduce...
Published on Jun 1, 2001in British Journal of Pharmacology 6.58
Jaye Chin-Dusting29
Estimated H-index: 29
,
Lisa J Fisher1
Estimated H-index: 1
+ 3 AuthorsAlan J. Husband31
Estimated H-index: 31
Legume-derived isoflavones such as genistein, diadzein and equol have been associated with a reduction in risk of cardiovascular disease. In the current study, we explore the vascular activity of several isoflavone metabolites namely dihydrodaidzein, cis and trans-tetrahydrodaidzein and dehydroequol for potential cardioprotective properties. Rat isolated aortic rings were used. 17β-oestradiol, equol, and all four of the metabolites studied significantly antagonized contractile responses to norad...
Published on Jan 16, 2001in Circulation 23.05
H. A. Walker2
Estimated H-index: 2
,
T. S. Dean1
Estimated H-index: 1
+ 3 AuthorsP. Chowienczyk51
Estimated H-index: 51
Background—Genistein, a phytoestrogen, may have estrogenic cardioprotective actions. We investigated whether genistein influences endothelium-dependent vasodilation in forearm vasculature of healthy human subjects and compared the effects of genistein with those of 17β-estradiol. Methods and Results—The brachial arterial was cannulated with a 27-gauge needle for drug infusion. Forearm blood flow responses were measured with strain-gauge plethysmography. Genistein (10 to 300 nmol/min, each dose f...
Published on Aug 1, 2000in The American Journal of Clinical Nutrition 6.57
Helen Wiseman30
Estimated H-index: 30
,
James O'reilly9
Estimated H-index: 9
+ 4 AuthorsThomas A. B. Sanders53
Estimated H-index: 53
Background: Oxidative damage to lipids may be involved in the etiology of atherosclerosis, cardiovascular disease in general, and cancer. The soy isoflavone phytoestrogens, genistein and daidzein, and equol (a daidzein metabolite produced by intestinal microflora) are antioxidants in vitro; equol is a particularly good inhibitor of LDL oxidation and membrane lipid peroxidation. Objective: We sought to investigate the effects of a diet enriched with soy containing isoflavones on in vivo biomarker...
Published on Aug 1, 2000in Journal of Nutrition 4.42
Kohsuke Matsumoto15
Estimated H-index: 15
(Kikkoman),
Mariusz K. Piskula27
Estimated H-index: 27
+ 5 AuthorsMamoru Kikuchi9
Estimated H-index: 9
(Kikkoman)
The antiatherogenic effect of soy protein with intact isoflavones is well established, but the effects of isoflavones without soy protein have not been determined. We investigated the antiatherogenic effect of an isoflavone aglycone-rich extract (containing 429.4 mg/g isoflavone aglycones) without soy protein from fermented soy in cholesterol-fed rabbits. We fed 12-wk-old New Zealand white male rabbits diets containing 1 g/100 g cholesterol with 0, 0.33 or 1 g/100 g isoflavone aglycones for 8 wk...
Published on Sep 27, 1999in JAMA Internal Medicine 20.77
John R. Crouse62
Estimated H-index: 62
,
Timothy R. Morgan60
Estimated H-index: 60
+ 3 AuthorsGregory L. Burke110
Estimated H-index: 110
Context Isolated soy protein reduces plasma concentrations of total and low-density lipoprotein (LDL) cholesterol. Objective To identify the agent(s) responsible for the cholesterol-lowering effect of soy in mildly hypercholesterolemic volunteers: isoflavones isolated together with soy protein or soy protein itself. Design Double-blind randomized parallel trial. Setting Single-center study. Participants A total of 156 healthy men and women with LDL cholesterol levels between 3.62 mmol/L (140 mg/...
Published on Mar 1, 1999in The Journal of Clinical Endocrinology and Metabolism 5.61
Paul J. Nestel66
Estimated H-index: 66
(La Trobe University),
Sylvia Pomeroy13
Estimated H-index: 13
(La Trobe University)
+ 4 AuthorsLeanne West3
Estimated H-index: 3
The possibility that the heightened cardiovascular risk associated with the menopause can be reduced by increasing dietary isoflavone intake was tested in 17 women by measuring arterial compliance, an index of the elasticity of large arteries such as the thoracic aorta. Compliance diminishes with age and menopause. An initial 3- to 4-week run-in period and a 5-week placebo period were followed by two 5-week periods of active treatment with 40 mg and then 80 mg isoflavones derived from red clover...
Cited By10
Newest
Published on Jan 1, 2014in Przegla̜d menopauzalny
Maria Gacek1
Estimated H-index: 1
Aim of the study was to analyze selected individual determinants of consumption of soy products and legumes by menopausal women. The analyzed individual characteristics included the level of general self-efficacy, optimism, and satisfaction with life. The study, using a questionnaire for the assessment of food product consumption frequency, and psychological tests (GSES, LOT-R, SWLS), was conducted in a group of 320 women aged between 45 and 55 years. Spearman’s coefficient of rank correlation a...
Published on Jan 1, 2013
Anwar Shahzad11
Estimated H-index: 11
(AMU: Aligarh Muslim University),
Arjumend Shaheen2
Estimated H-index: 2
(AMU: Aligarh Muslim University)
+ 2 AuthorsShiwali Sharma6
Estimated H-index: 6
(AMU: Aligarh Muslim University)
Plants are valuable sources for the discovery of new products of medicinal importance. Several distinct chemicals and compounds derived from plants are being used as important drugs all around the world. The evolving commercial importance of secondary metabolites in recent years resulted in a great interest in secondary metabolism, particularly in the possibility of altering the production of bioactive plant metabolites by means of plant tissue culture technology. Plant tissue culture techniques...
Published on May 1, 2012in European Journal of Lipid Science and Technology 1.85
M. Benito6
Estimated H-index: 6
(University of Zaragoza),
José Manuel Lasa Dolhagaray15
Estimated H-index: 15
(CSIC: Spanish National Research Council)
+ 3 AuthorsAna Cristina Sánchez-Gimeno7
Estimated H-index: 7
(University of Zaragoza)
Phenolic compounds have a high importance in olive oil because of their effect on shelf life and sensory properties. This study reports on the HPLC profiles of the phenolic compounds of virgin olive oils obtained from Arbequina olives from the harvesting in a super-intensive orchard under a linear irrigation system. In addition, phenolic content, carotenoid and chlorophyllic pigments, and oxidative stability were analyzed. Total phenol content and 3,4-DHPEA-EDA increased up to a maximum througho...
G. El-Diwani2
Estimated H-index: 2
,
S. El-Rafie2
Estimated H-index: 2
,
S. Hawash10
Estimated H-index: 10
The Egyptian Jatropha crop has been studied for antioxidant activity in ethanol extracts from roots, stem, leaves and nodes. The radical scavenging activity of ethanolic extracts was evaluated with the stable diphenylpicryl-hydrazyl (DPPH) free radical. The antioxidant capacity of the studied organs have been revealed the roots and stem were the strongest in all tests followed by leaves and nodes were the least. All the extracts showed radical scavenging activity. Roots crude extract showed IC50...
K.G. Nevin1
Estimated H-index: 1
(UoK: University of Kerala),
T. Rajamohan1
Estimated H-index: 1
(UoK: University of Kerala)
Summary Background aims Experimental and epidemiological studies indicate an association between dietary saturated fatty acids and thrombosis, but the effects of individual fatty acids on haemostasis are still controversial. The purpose of this research is to evaluate the effect of feeding virgin coconut oil (VCO) on blood coagulation factors, lipid levels and in vitro oxidation of LDL in comparison with copra oil (CO) and sunflower oil (SFO) in cholesterol (1%) and oil (10% w/w) fed rats. Metho...
Published on Dec 1, 2007in Journal of The American College of Nutrition 2.08
Christopher D. Gardner35
Estimated H-index: 35
(Stanford University),
Mark Messina36
Estimated H-index: 36
(LLU: Loma Linda University)
+ 2 AuthorsAdrian A. Franke50
Estimated H-index: 50
Objective: To compare the effects of two commercially available soy milks (one made using whole soy beans, the other using soy protein isolate) with low-fat dairy milk on plasma lipid, insulin, and glucose responses.Design: Randomized clinical trial, cross-over design.Subjects: Participants were 30–65 years of age, n = 28, with pre-study LDL-cholesterol (LDL-C) concentrations of 160–220 mg/dL, not on lipid lowering medications, and with an overall Framingham risk score of ≤10%.Intervention: Part...
Published on Aug 6, 2007in Molecules 3.06
Alessandra Bendini36
Estimated H-index: 36
,
Lorenzo Cerretani36
Estimated H-index: 36
+ 4 AuthorsGiovanni Lercker21
Estimated H-index: 21
Among vegetable oils, virgin olive oil (VOO) has nutritional and sensory characteristics that to make it unique and a basic component of the Mediterranean diet. The importance of VOO is mainly attributed both to its high content of oleic acid a balanced contribution quantity of polyunsaturated fatty acids and its richness in phenolic compounds, which act as natural antioxidants and may contribute to the prevention of several human diseases. The polar phenolic compounds of VOO belong to different...
Published on Aug 1, 2007
A. Nandutu1
Estimated H-index: 1
(MUK: Makerere University),
Michael N. Clifford52
Estimated H-index: 52
(University of Surrey),
Nazlin K. Howell27
Estimated H-index: 27
Sweet potato varieties: Nsp, Tz and Spk obtained from Uganda were used in this study. Several phenolic compounds were identified on the basis of their mass spectra in full scan mode and the pattern of their fragmentation. The major compounds found were caffeoylquinic acid, dicaffeoylquinic acid, coumaroylquinic acid, feruloylquinic acid and caffeoylferuloylquinic acids. This is the first time that caffeoylferuloylquinic isomers have been identified in sweet potato samples. Key words:
Published on Dec 1, 2006in Indian Journal of Experimental Biology
Kamlesh Vaishnav1
Estimated H-index: 1
,
Shaily Goyal7
Estimated H-index: 7
,
Kishan G. Ramawat11
Estimated H-index: 11
Isoflavonoid contents of different plant parts and callus tissues of the Indian Kudzu, Pueraria tuberosa (Roxb.ex.Willd.) DC are presented. The initial cultures were slow growing, associated with browning of the tissues. The production of four isoflavonoids (puerarin, genistin, genistein and daidzein) in the callus cultures of P. tuberosa was studied by manipulating the plant growth regulators and sucrose concentration in the medium. Organogenesis was not recorded in callus on any of these treat...