The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

Volume: 106, Issue: 42, Pages: 17858 - 17863
Published: Oct 20, 2009
Abstract
NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC class I proteins and are expressed in a variegated fashion. It was recently shown that TIGIT, a new protein expressed by T and NK cells binds to PVR and PVR-like receptors and inhibits T cell activity indirectly through the manipulation of DC activity. Here, we show that TIGIT is expressed by all human NK cells, that...
Paper Details
Title
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
Published Date
Oct 20, 2009
Volume
106
Issue
42
Pages
17858 - 17863
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