Mitochondrial function in intact skeletal muscle fibres of creatine kinase deficient mice
Abstract
Creatine kinase (CK) has a central role in skeletal muscle, acting as a fast energy buffer and shuttle between sites of energy production (mitochondria) and consumption (cross-bridges and ion pumps). Unexpectedly, isolated fast-twitch skeletal muscle cells of mice deficient in both cytosolic and mitochondrial CK (CK-/-) are highly fatigue resistant during stimulation protocols that stress aerobic metabolism. We have now studied different aspects...
Paper Details
Title
Mitochondrial function in intact skeletal muscle fibres of creatine kinase deficient mice
Published Date
Oct 1, 2003
Journal
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