161. Effects of MAGL inhibition and the CB1 and CB2 cannabinoids receptors participation in the neutrophils recruitment and activity in a murine model of acute lung injury induced by LPS

Endocannabinoid signaling is terminated by enzymatic hydrolysis; process that 2-Arachidonoylglycerol (2-AG) is mediated by monoacylglycerol lipase (MAGL). The MAGL inhibition increases 2-AG levels, an endocannabinoid that acts on CB1 and CB2 receptors. In inflammation, the neutrophils are the first leukocytes to migrate to the injury focus. The aim was to investigate the effects of MAGL inhibition (with JZL184) in the neutrophils recruitment and...