Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery
Abstract
We hypothesized that pH-responsive carboxymethylated kappa-carrageenan microparticles could protect entrapped oral insulin from acidic and proteolytic degradation in the gastrointestinal tract. Therefore, the objectives of this study were to prepare and characterize insulin entrapped in lectin-functionalized carboxymethylated kappa-carrageenan microparticles and to evaluate their therapeutic efficacy in vitro and in vivo. The encapsulation of...
Paper Details
Title
Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery
Published Date
Aug 1, 2011
Journal
Volume
86
Issue
2
Pages
555 - 565
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