Deterministic direct reprogramming of somatic cells to pluripotency

Nature64.80
Volume: 502, Issue: 7469, Pages: 65 - 70
Published: Oct 3, 2013
Abstract
Somatic cells can be inefficiently and stochastically reprogrammed into induced pluripotent stem (iPS) cells by exogenous expression of Oct4 (also called Pou5f1), Sox2, Klf4 and Myc (hereafter referred to as OSKM). The nature of the predominant rate-limiting barrier(s) preventing the majority of cells to successfully and synchronously reprogram remains to be defined. Here we show that depleting Mbd3, a core member of the Mbd3/NuRD (nucleosome...
Paper Details
Title
Deterministic direct reprogramming of somatic cells to pluripotency
Published Date
Oct 3, 2013
Journal
Volume
502
Issue
7469
Pages
65 - 70
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.