Original paper
α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation
Abstract
Although islet transplantation for individuals with type 1 diabetes has been shown to yield superior blood glucose control, it remains inadequate for long-term control. This is partly due to islet injuries and stresses that can lead to beta cell loss. Inhibition of excess IL-1β activity might minimize islet injuries, thus preserving function. The IL-1 receptor antagonist (IL-1Ra), an endogenous inhibitor of IL-1β, protects islets from...
Paper Details
Title
α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation
Published Date
Apr 7, 2014
Volume
11
Issue
4
Pages
377 - 386
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Notes
History