Abstract A13: Selective role of iNOS reveals its negative regulatory influence on the expression of TNFR1, NF-κB and other cell survival signaling events during a P19-induced apoptosis in HL-60 cells

P19, a semi-synthetic analog of sesquiterpene lactone ‘Parthenin’, is a promising template to develop into novel anti-cancer leads. P19 induced robust cell death in human leukemia cell lines compared to normal cells when observed after 48h treatment with IC50 of 3.5 μM in HL-60 cells to that of 35 μM in human normal gingival fibroblast cells. Mechanistic studies into HL-60 cells death after 6 h exposure to 10 μM P19 were investigated. It killed...