Match!

Fat as an endocrine organ: Relationship to the metabolic syndrome

Published on Dec 1, 2005in The American Journal of the Medical Sciences1.96
· DOI :10.1097/00000441-200512000-00005
Louise J. Hutley15
Estimated H-index: 15
(UQ: University of Queensland),
John Prins59
Estimated H-index: 59
(UQ: University of Queensland)
Cite
Abstract
Obesity and the metabolic syndrome have both reached pandemic proportions. Together they have the potential to impact on the incidence and severity of cardiovascular pathologies, with grave implications for worldwide health care systems. The metabolic syndrome is characterized by visceral obesity, insulin resistance, hypertension, chronic inflammation, and thrombotic disorders contributing to endothelial dysfunction and, subsequently, to accelerated atherosclerosis. Obesity is a key component in development of the metabolic syndrome and it is becoming increasingly clear that a central factor in this is the production by adipose cells of bioactive substances that directly influence insulin sensitivity and vascular injury. In this paper, we review advances in the understanding of biologically active molecules collectively referred to as adipokines and how dysregulated production of these factors in obese states mediates the pathogenesis of obesity associated metabolic syndrome.
  • References (188)
  • Citations (212)
Cite
References188
Newest
Published on Jun 28, 2008in Clinical and Experimental Immunology3.71
Rosamonde E. Banks50
Estimated H-index: 50
(St James's University Hospital),
M. A. Forbes9
Estimated H-index: 9
(St James's University Hospital)
+ 7 AuthorsJ. T. Whicher1
Estimated H-index: 1
(St James's University Hospital)
IL-6, tumour necrosis factor-alpha (TNF-alpha) and IL-1 are thought to be the key mediators of the acute phase response although much of the evidence is based on in vitro studies. It is not clear to what extent each of the acute phase proteins are regulated in vivo by each of these cytokines. The aim of this study was to examine the effects of IL-6 treatment in eight patients with cancer on the concentrations of an extensive range of positive and negative acute phase proteins. It was part of a l...
Published on Jun 28, 2008in Annals of the New York Academy of Sciences4.29
T J Podor5
Estimated H-index: 5
(Scripps Health),
Frank R. Jirik9
Estimated H-index: 9
(Scripps Health)
+ 2 AuthorsMartin Lotz84
Estimated H-index: 84
(Scripps Health)
Susan Kralisch30
Estimated H-index: 30
,
Johannes E. M. N. Klein25
Estimated H-index: 25
+ 4 AuthorsMathias Fasshauer52
Estimated H-index: 52
Visfatin is a novel adipocytokine exerting insulin-mimetic effects in various insulin-sensitive tissues such as liver, muscle, and fat. In contrast, interleukin (IL)-6 is a proinflammatory adipose-secreted factor that induces insulin resistance and plasma concentrations that correlate with the development of type 2 diabetes mellitus. In the present study, the impact of IL-6 on visfatin gene expression in 3T3-L1 adipocytes was determined by quantitative real-time reverse transcription-polymerase ...
Published on Aug 1, 2005in Endocrinology3.80
Peter J. Klover5
Estimated H-index: 5
(UR: University of Rochester),
Alicia H. Clementi4
Estimated H-index: 4
(UR: University of Rochester),
Robert A. Mooney32
Estimated H-index: 32
(UR: University of Rochester)
Obesity and insulin resistance are considered chronic inflammatory states, in part because circulating IL-6 is elevated. Exogenous IL-6 can induce hepatic insulin resistance in vitro and in vivo. The importance of endogenous IL-6, however, to insulin resistance of obesity is unresolved. To test the hypothesis that IL-6 contributes to the inflammation and insulin resistance of obesity, IL-6 was depleted in Lepob mice by injection of IL-6-neutralizing antibody. In untreated Lepob mice, signal tran...
Published on Jun 1, 2005in Hypertension7.02
Yoshio Iwashima22
Estimated H-index: 22
,
Tomohiro Katsuya52
Estimated H-index: 52
+ 9 AuthorsTohru Funahashi104
Estimated H-index: 104
Adiponectin is emerging as an important molecule in obesity, the metabolic syndrome, and cardiovascular disease. On the other hand, smoking habit is well known to be related to cardiovascular disease and hypertension. To examine the association between adiponectin concentration and smoking habit, we performed an epidemiological survey and an acute exposure test in humans and an experiment in adipocytes to elucidate the mechanism underlying the association between adiponectin and smoking. In the ...
Published on Jun 1, 2005in Journal of Endocrinology4.38
Susan Kralisch30
Estimated H-index: 30
,
Johannes E. M. N. Klein25
Estimated H-index: 25
+ 4 AuthorsMathias Fasshauer52
Estimated H-index: 52
Recently, visfatin was characterized as a novel adipocytokine that is upregulated in obesity and exerts insulinmimetic effects in various tissues. To clarify expression and regulation of this adipocytokine, visfatin mRNA was measured by quantitative real-time reverse transcriptionpolymerase chain reaction in 3T3-L1 adipocytes during adipogenesis and after treatment with various hormones known to alter insulin sensitivity. Visfatin expression was about 6-fold higher in 3T3-L1 adipocytes in vitro ...
Published on Jun 1, 2005in Diabetologia7.11
Yoshiyuki Hattori35
Estimated H-index: 35
(Dokkyo University),
Kazumi Akimoto26
Estimated H-index: 26
(Dokkyo University)
+ 2 AuthorsKikuo Kasai32
Estimated H-index: 32
(Dokkyo University)
Aims/hypothesis Hypertension, endothelial dysfunction and insulin resistance are associated conditions that share oxidative stress and vascular inflammation as common features. Adiponectin is an abundant plasma adipokine that plays a physiological role in modulating lipid metabolism and exerts a potent anti-inflammatory activity. We hypothesised that adiponectin levels decrease in response to oxidative stress and that this may promote the development of hypertension, endothelial dysfunction and ...
Published on May 13, 2005in Circulation Research15.86
Anders H Berg A H31
Estimated H-index: 31
(Yeshiva University),
Philipp E. Scherer111
Estimated H-index: 111
Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk. Circulating mediators of inflammation participate in the mechanisms of vascular insult and atheromatous change, and many of these inflammatory proteins are secreted directly from adipocytes and adipose tissue–derived macrophages. Several factors linking obesity with an increased cardiovascular risk have been ident...
Published on May 6, 2005in Journal of Biological Chemistry
Yu Wang54
Estimated H-index: 54
(University of Auckland),
Karen S.L. Lam66
Estimated H-index: 66
(HKU: University of Hong Kong)
+ 4 AuthorsAimin Xu68
Estimated H-index: 68
(University of Auckland)
Abstract Adiponectin, an adipocyte-specific secretory protein, is present in serum as three oligomeric complexes. Apart from its roles as an anti-diabetic and anti-atherogenic hormone, adiponectin has been implicated as an important regulator of cell growth and tissue remodeling. Here we show that some of these functions might be mediated by the specific interactions of adiponectin with several important growth factors. Among six different growth factors examined, adiponectin was found to bind w...
Published on May 6, 2005in Journal of Biological Chemistry
Aimin Xu68
Estimated H-index: 68
(University of Auckland),
Kok Weng Chan4
Estimated H-index: 4
(HKU: University of Hong Kong)
+ 8 AuthorsGarth J. S. Cooper56
Estimated H-index: 56
(University of Auckland)
Abstract The antidiabetic hormone adiponectin circulates in blood as several oligomeric complexes, and the ratios between them are critical in determining insulin sensitivity. In this study we investigated the role of testosterone in regulating the oligomeric complex distribution of adiponectin. Gel filtration analysis revealed that circulating adiponectin existed as the forms of high molecular weight (HMW), middle molecular weight, and low molecular weight complexes in both human and mice. The ...
Cited By212
Newest
Published on May 1, 2019in Endocrine3.30
Anusha Singh3
Estimated H-index: 3
(BHU: Banaras Hindu University),
Joseph R.D. Fernandes2
Estimated H-index: 2
(BITS: Birla Institute of Technology and Science)
+ 2 AuthorsArnab Banerjee9
Estimated H-index: 9
(BITS: Birla Institute of Technology and Science)
Purpose The incidence of obesity is increasing among all age groups throughout the world and it is highly associated with numerous other metabolic disorders, such as insulin resistance, polycystic ovarian syndrome (PCOS) etc.
Published on Jan 1, 2019
Esteban Porrini21
Estimated H-index: 21
(Hospital Universitario de Canarias),
Maruja Navarro-Díaz (Autonomous University of Barcelona)+ 1 AuthorsEduardo Salido33
Estimated H-index: 33
(Hospital Universitario de Canarias)
The pandemic of metabolic syndrome (MS), obesity, and type 2 diabetes – diabesity – may portend severe consequences in renal disease. In patients with obesity and particularly in extreme obesity, obesity-related glomerulopathy (ORG) is the classical picture of renal damage. ORG is characterized by glomerulomegaly and a secondary form of focal and segmental glomerulosclerosis. Interestingly, 50% of the cases with ORG also have “diabetoid changes” including mesangial expansion mainly in the absenc...
Published on Dec 1, 2018in Journal of Dairy Science3.08
Hannes Bogaert2
Estimated H-index: 2
(UGent: Ghent University),
J. De Koster5
Estimated H-index: 5
(UGent: Ghent University)
+ 2 AuthorsGeert Opsomer25
Estimated H-index: 25
(UGent: Ghent University)
In the present study, we tested the hypothesis that overconditioning in dairy cows at the end of the dry period leads to infiltration of fat and alterations of the insulin secretory capacity of the pancreas. Pregnant Holstein Friesian dairy cows were selected based on body condition score (BCS) at the start of the dry period. Body condition score varied between cows to have optimal conditioned (2.5 < BCS <= 3.5, n = 5) and overconditioned (3.5 < BCS <= 5, n = 5) cows. All animals underwent an in...
Published on Nov 1, 2018in World Journal of Surgery2.77
Akihiko Okamura5
Estimated H-index: 5
(JFCR: Japanese Foundation for Cancer Research),
Masayuki Watanabe36
Estimated H-index: 36
(JFCR: Japanese Foundation for Cancer Research)
+ 5 AuthorsShinji Mine8
Estimated H-index: 8
(JFCR: Japanese Foundation for Cancer Research)
Background Esophagectomy for esophageal cancer is one of the most invasive surgeries. However, the factors influencing postoperative systemic inflammatory response following esophagectomy have not been elucidated. Recently, visceral fat has been shown to play an important role in both chronic and acute inflammation. In this study, we assessed the relationship between visceral obesity and postoperative inflammatory response following minimally invasive esophagectomy (MIE).
Published on Jul 1, 2018in Cytometry Part B-clinical Cytometry2.94
Ralph Wonner1
Estimated H-index: 1
,
Stefan Wallner6
Estimated H-index: 6
+ 1 AuthorsGerdSchmitz78
Estimated H-index: 78
Objective Acute exercise induces numerous changes in peripheral blood, e.g. counts of leukocytes. CD16pos monocytes, which play a role in the pathogenesis of arteriosclerosis and the metabolic syndrome (MetS), are among the blood cells with the highest fold increase through exercise. So far no studies have investigated the effect of exercise on the blood cell composition of patients with MetS. Approach and Results Blood cell counts, a wide panel of laboratory tests, as well as lipid and protein ...
Published on Jun 19, 2018in Bioinorganic Chemistry and Applications2.58
Samuel Treviño7
Estimated H-index: 7
(BUAP: Benemérita Universidad Autónoma de Puebla),
Alfonso Díaz12
Estimated H-index: 12
(BUAP: Benemérita Universidad Autónoma de Puebla)
+ 5 AuthorsEnrique González-Vergara10
Estimated H-index: 10
(BUAP: Benemérita Universidad Autónoma de Puebla)
Vanadium(IV/V) compounds have been studied as possible metallopharmaceutical drugs against diabetes mellitus. However, mechanisms of action and toxicological threshold have been tackled poorly so far. In this paper, our purposes were to evaluate the metabolic activity on dyslipidemia and dysglycemia, insulin signaling in liver and adipose tissue, and toxicology of the title compound. To do so, the previously reported bisammonium tetrakis 4-(N,N-dimethylamino)pyridinium decavanadate, the formula ...
Published on Apr 1, 2018in Journal of Obstetrics and Gynaecology Research1.12
Min Shang1
Estimated H-index: 1
(Capital Medical University),
Xu Dong1
Estimated H-index: 1
(Capital Medical University),
Lin Hou1
Estimated H-index: 1
(Capital Medical University)
Published on Jan 1, 2018in CardioRenal Medicine2.21
Zhouping Zou2
Estimated H-index: 2
,
Yamin Zhuang3
Estimated H-index: 3
+ 6 AuthorsXiaoqiang Ding20
Estimated H-index: 20
Background/Aims: To explore the association of body mass index (BMI) with the risk of developing acute kidney injury after cardiac surgery (CS-AKI) and for AKI requiring renal replacement therapy (AKI-RRT) after cardiac surgery. Methods: Clinical data of 8,455 patients undergoing cardiac surgery, including demographic preoperative, intraoperative, and postoperative data were collected. Patients were divided into underweight (BMI Results: The mean age of the patients was 53.2 ± 13.9 years. The ov...
Published on Jan 1, 2018in Peptides2.66
Panayoula C. Tsiotra14
Estimated H-index: 14
,
Panagiotis Halvatsiotis1
Estimated H-index: 1
(UoA: National and Kapodistrian University of Athens)
+ 5 AuthorsEleni Boutati23
Estimated H-index: 23
(UoA: National and Kapodistrian University of Athens)
Abstract Maternal adipose tissue and the placenta secrete various molecules commonly called adipokines such as chemerin, omentin-1, visfatin, adiponectin, and leptin that are important players in the pathogenesis of insulin resistance. Gestational diabetes mellitus (GDM) is defined as a state of glucose intolerance characterized by β-cell dysfunction and insulin resistance. To examine whether circulating adipokines and their mRNA expression in the adipose tissue and the placenta are altered in G...
Published on Dec 1, 2017in BBA clinical
Marco G. Alves26
Estimated H-index: 26
(University of Porto),
Ângela Moreira2
Estimated H-index: 2
(University of Porto)
+ 4 AuthorsMariana P. Monteiro15
Estimated H-index: 15
(University of Porto)
Abstract Adipose tissue (AT) is involved in dysmetabolism pathogenesis. Regional fat distribution and functioning may contribute to obesity-related metabolic disorders and adverse health outcomes. Specific fat depots are suggested to possess unique biological properties, but specific metabolic profiles of subcutaneous (SAT) and visceral adipose tissue (VAT) remain unknown. We aimed to characterize VAT and SAT glucose metabolism, and their correlation with body mass index (BMI). AT samples from p...
View next paperDiagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement