Original paper
Identifying protein construct variants with increased crystallization propensity––A case study
Abstract
This study describes an efficient multiparallel automated workflow of cloning, expression, purification, and crystallization of a large set of construct variants for isolated protein domains aimed at structure determination by X‐ray crystallography. This methodology is applied to MAPKAP kinase 2, a key enzyme in the inflammation pathway and thus an attractive drug target. The study reveals a distinct subset of truncation variants with improved...
Paper Details
Title
Identifying protein construct variants with increased crystallization propensity––A case study
Published Date
Dec 1, 2006
Journal
Volume
15
Issue
12
Pages
2718 - 2728
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Notes
History