Original paper
How insulin engages its primary binding site on the insulin receptor
Abstract
Insulin receptor signalling has a central role in mammalian biology, regulating cellular metabolism, growth, division, differentiation and survival. Insulin resistance contributes to the pathogenesis of type 2 diabetes mellitus and the onset of Alzheimer's disease; aberrant signalling occurs in diverse cancers, exacerbated by cross-talk with the homologous type 1 insulin-like growth factor receptor (IGF1R). Despite more than three decades of...
Paper Details
Title
How insulin engages its primary binding site on the insulin receptor
Published Date
Jan 1, 2013
Journal
Volume
493
Issue
7431
Pages
241 - 245
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Notes
History