Induction of Nitric Oxide Synthase in Rat C6 Glioma Cells

: We have examined the induction of nitric oxide syhthase (NOS) activity in the rat astrocyte‐derived C6 glioma cell line. In contrast to the previous results with primary astrocyte cultures, incubation of C6 cells with bacterial endotoxin lipopolysaccharide (LPS; 1 μg/ml for 24 h) did not stimulate NO 2 production. However, addition of either tumor necrosis factor‐a (TNF‐α) or interferon‐γ (IFN‐γ), cytokines that by themselves had no effect on...