Comparison of several oximes on reactivation of soman-inhibited blood, brain and tissue cholinesterase activity in rats

The ability of three oximes, HI-6, MMB-4 and ICD-467, to reactivate cholinesterase (ChE) inhibited by the organophosphorus compound soman was compared in blood (plasma and erythrocytes), brain regions (including spinal cord) and peripheral tissues of rats. Animals were intoxicated with soman (100 μg/kg, SC; equivalent to 0.9 × LD50 dose) and treated 1 min later with one of these oximes (100 or 200 μmol/kg, IM). Toxic sign scores and total tissue...