The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4′-azidocytidine (R1479)
Volume: 19, Issue: 15, Pages: 4250 - 4254
Published: Aug 1, 2009
Abstract
We report the design, synthesis and evaluation of a family of ca 50 phosphoramidate ProTides of the potent anti-HCV compound 4′-azidocytidine (R1479), with variation on the ester, amino acid and aryl moiety of the ProTide. Sub-μM inhibitors of HCV emerge. The compounds are all non-cytotoxic in the replicon assay. We herein report detailed SARs for each of the regions of the...
Paper Details
Title
The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4′-azidocytidine (R1479)
Published Date
Aug 1, 2009
Volume
19
Issue
15
Pages
4250 - 4254
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