Interactions of anticancer drugs with biomembranes: What can we learn from model membranes?

The interactions of anticancer drugs with cell membranes are of primary importance for drug transport, accumulation and activity. However, these interactions are very difficult to investigate because of the complexity of biological membranes. Lipid model membranes have therefore been built to gain insight into the collective role of lipids in drug–membrane interactions. Membranes can act as a barrier for drug molecules, sequester them or...