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Occupation as a risk factor for oral and pharyngeal cancer
Abstract
Abstract Introduction and objectives Oral and pharyngeal cancers represent the fifth most common cancer type and the seventh cause of deaths by cancer worldwide. Few studies have assessed the risks associated with occupational exposure and in many cases the results are contradictory. The objective of this study is to determine the association between occupational exposure to carcinogenic substances and risk of oral and pharyngeal cancer (including nasopharynx and hypopharynx) through a systematic review. Material and methods A literature search was carried out in MEDLINE (PubMed) and EMBASE. The articles were selected by two independent investigators on the basis of inclusion and exclusion criteria (sample size, publication type, etc.). Results Ten original articles were included, all with a case-control design. The results showed that a prolonged exposure to formaldehyde may increase the risk of nasopharyngeal and hypopharyngeal cancer, whilst other chemical products were not associated with these tumours. The exposure to different types of particles (such as wood dust in nasopharyngeal cancer) and smoke of various origins has also been associated with several oral and pharyngeal tumours. Conclusions The literature reviewed shows that occupational exposure to formaldehyde may be associated with an increased risk of nasopharyngeal and hypopharyngeal cancer. The results regarding other occupational exposures are not consistent, therefore additional studies with more statistical power and better design are needed to ascertain if occupation is really a relevant risk factor for these types of cancer.

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  • References (31)
  • Cited By (5)
M Marmot1
Estimated H-index: 1
,
T Atinmo1
Estimated H-index: 1
,
T Byers1
Estimated H-index: 1
... more
This Report has a number of inter-related general purposes. One is to explore the extent to which food, nutrition, physical activity, and body composition modify the risk of cancer, and to specify which factors are most important. To the extent that environmental factors such as food, nutrition, and physical activity influence the risk of cancer, it is a preventable disease. The Report specifies recommendations based on solid evidence which, when followed, will be expected to reduce the incidenc...
3,469 Citations Source
2000 in British Journal of Cancer [IF: 5.92]
Cristina Bosetti66
Estimated H-index: 66
,
E. Negri71
Estimated H-index: 71
,
Silvia Franceschi128
Estimated H-index: 128
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We analysed two case–control studies of women from Italy and Switzerland, including 195 cases of oral and pharyngeal cancers and 1113 controls. The multivariate odds ratio was 4.6 for heavy smokers and 2.7 for high alcohol intake. Vegetables, fruit, β-carotene and wholegrain foods were inversely, butter and retinol directly, related to risk. © 2000 Cancer Research Campaign
50 Citations Source Cite
Joseph B. Coble1
Estimated H-index: 1
,
Linda Morris Brown55
Estimated H-index: 55
,
Richard B. Hayes69
Estimated H-index: 69
... more
The work history information from a population-based case-control study conducted in Puerto Rico was analyzed using a job exposure matrix to investigate the relationship between occupational exposures and cancers of the oral cavity or pharynx. After adjustment for age, alcohol, smoking, and residence in a logistic model, the risk for cancer of the oral cavity, but not the pharynx, was significantly elevated among farm workers in the sugarcane industry (OR = 4.4, 95% CI = 1.4-13.6). An exposure-r...
24 Citations Source Cite
1999 in Oncology Reports [IF: 2.98]
E B Schildt1
Estimated H-index: 1
,
M Eriksson1
Estimated H-index: 1
,
Lennart Hardell46
Estimated H-index: 46
... more
Occupational exposures as risk factors for oral cancer evaluated in a Swedish case-control study.
23 Citations Source Cite
Paquerette Goldberg11
Estimated H-index: 11
,
Annette Leclerc45
Estimated H-index: 45
,
Danièle Luce32
Estimated H-index: 32
... more
OBJECTIONS: To ascertain whether certain occupations are associated with laryngeal or hypopharyngeal cancer. METHODS: A hospital based case-control study was carried out in 15 hospitals in France. It included 528 male cases diagnosed between January 1989 and April 1991, and 305 male controls with various other types of cancer. Interviews were carried out to obtain lifetime job histories and information on potential confounders. Logistic regression was used to compute the odds ratios (OR) for eac...
46 Citations Source Cite
Timo Kauppinen40
Estimated H-index: 40
,
Timo Partanen33
Estimated H-index: 33
,
Sven Hernberg29
Estimated H-index: 29
... more
A case-control study of respiratory cancer, nested within a cohort of male woodworkers, was updated in Finland. The update extended the initial follow up of 3805 workers from 19 plants to 7307 workers from 35 plants. Each case of respiratory cancer (n = 136) diagnosed between 1957 and 1982 within the cohort was matched by year of birth with three controls (n = 408) from the cohort. Chemical exposures were assessed for the cases and the controls by a plant and period specific job exposure matrix....
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Per Gustavsson34
Estimated H-index: 34
,
Robert Jakobsson8
Estimated H-index: 8
,
Hemming Johansson35
Estimated H-index: 35
... more
OBJECTIVES: This community based case-referent study was initiated to investigate aetiological factors for squamous cell carcinoma of the upper gastrointestinal tract. METHODS: The study was based on all Swedish men aged 40-79 living in two regions of Sweden during 1988-90. Within that base, efforts were made to identify all incident cases of squamous cell carcinoma of the oral cavity, oropharynx and hypopharynx, larynx, and oesophagus. Referents were selected as a stratified (age, region) rando...
105 Citations Source Cite
Gary M. Marsh31
Estimated H-index: 31
,
Philip E. Enterline22
Estimated H-index: 22
,
Roslyn A. Stone34
Estimated H-index: 34
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We report here on the phase of our surveillance program, which involved a 3-year 1985 mortality update of the original US MMMF cohort study only. As before, interest is focused on respiratory cancer, malignant mesotheliomas, and nonmalignant respiratory disease
65 Citations Source Cite
2006 in Cadernos De Saude Publica [IF: 0.97]
Magda Andreotti1
Estimated H-index: 1
(University of São Paulo),
Aparecida Natália Rodrigues1
Estimated H-index: 1
(University of São Paulo),
Luiza Maria Nunes Cardoso1
Estimated H-index: 1
... more
Estudo caso-controle conduzido para avaliar a associacao de exposicoes ocupacionais e câncer oral e orofaringe na Regiao Metropolitana de Sao Paulo. Inclui 325 casos e 468 controles, recrutados por frequencia de sexo e faixa etaria, entrevistados entre janeiro de 1999 e marco de 2002. A analise por ramos de atividade e ocupacoes foi restrita aos homens (266 casos, 362 controles) e os odds ratios (OR), calculados por regressao logistica nao-condicional, foram controlados por idade, tabagismo e co...
27 Citations Download PDF Cite
  • References (31)
  • Cited By (5)
Cancer is a complex disease wherein mutations in protein-encoding genes lead to numerous tempo-spatial changes in cell physiology, ultimately leading to malignant tumors. Indian Population Based Cancer Registries documents incidences of cancers across the country and it was reported that highest Age Adjusted Rates was found in cancers of the tongue, hypopharynx and oesophagus which are head and neck cancers. They are amongst the commonest malignancies, accounting for approximately 20% of the can...
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Sie Sie Siew1
Estimated H-index: 1
,
Timo Kauppinen40
Estimated H-index: 40
,
Pentti Kyyrönen30
Estimated H-index: 30
... more
Controversy exists over whether or not occupational inhalation exposure to wood dust and/or formaldehyde increases risk for respiratory cancers. The objective of this study was to examine the risk of nasal, nasopharyngeal, and lung cancer in relation to occupational exposure to wood dust and formaldehyde among Finnish men. The cohort of all Finnish men born between the years 1906 and 1945 and in employment during 1970 was followed up through the Finnish Cancer Registry for cases of cancers of th...
26 Citations Source Cite
2015 in Carcinogenesis [IF: 5.07]
Josiah Ochieng23
Estimated H-index: 23
(Meharry Medical College),
Gladys N. Nangami5
Estimated H-index: 5
(Meharry Medical College),
Olugbemiga Ogunkua2
Estimated H-index: 2
(Meharry Medical College)
... more
The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of lowdose environmental mixtures and carcinogens in the promotion of invasion and metastasis in specific tumors such as breast and prostate, the overarching theme is the role of low-dose carcinogens in the progression of cancer stem cells. It is becoming clearer t...
15 Citations Download PDF Cite
2015 in PLOS ONE [IF: 2.77]
Montserrat Alonso-Sardón5
Estimated H-index: 5
(University of Salamanca),
Antonio-J. Chamorro1
Estimated H-index: 1
(University of Salamanca),
Ignacio Hernández-García2
Estimated H-index: 2
... more
Objective To perform a systematic review to analyze the association between occupational exposure to wood dust and cancer. Methods A systematic literature search of entries made in the MEDLINE-PubMed database between 1957 and 2013 was conducted to identify studies that had assessed the relationship between occupational exposure to wood dust and different types of cancer. A meta-analysis of selected case-control and cohort studies was subsequently performed. Results A total of 114 studies were id...
8 Citations Source Cite

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