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Occupation as a risk factor for oral and pharyngeal cancer

Published on Jan 1, 2010in Acta Otorrinolaringologica
· DOI :10.1016/S2173-5735(10)70068-5
Jeannette Puñal-Riobóo4
Estimated H-index: 4
,
Leonor Varela-Lema5
Estimated H-index: 5
+ 2 AuthorsAlberto Ruano-Ravina23
Estimated H-index: 23
(Ciber)
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Abstract
Abstract Introduction and objectives Oral and pharyngeal cancers represent the fifth most common cancer type and the seventh cause of deaths by cancer worldwide. Few studies have assessed the risks associated with occupational exposure and in many cases the results are contradictory. The objective of this study is to determine the association between occupational exposure to carcinogenic substances and risk of oral and pharyngeal cancer (including nasopharynx and hypopharynx) through a systematic review. Material and methods A literature search was carried out in MEDLINE (PubMed) and EMBASE. The articles were selected by two independent investigators on the basis of inclusion and exclusion criteria (sample size, publication type, etc.). Results Ten original articles were included, all with a case-control design. The results showed that a prolonged exposure to formaldehyde may increase the risk of nasopharyngeal and hypopharyngeal cancer, whilst other chemical products were not associated with these tumours. The exposure to different types of particles (such as wood dust in nasopharyngeal cancer) and smoke of various origins has also been associated with several oral and pharyngeal tumours. Conclusions The literature reviewed shows that occupational exposure to formaldehyde may be associated with an increased risk of nasopharyngeal and hypopharyngeal cancer. The results regarding other occupational exposures are not consistent, therefore additional studies with more statistical power and better design are needed to ascertain if occupation is really a relevant risk factor for these types of cancer.
  • References (31)
  • Citations (5)
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References31
Newest
Published on Mar 1, 2006in Cadernos De Saude Publica 1.17
Magda Andreotti1
Estimated H-index: 1
(USP: University of São Paulo),
Aparecida Natália Rodrigues1
Estimated H-index: 1
(USP: University of São Paulo)
+ 3 AuthorsVictor Wünsch-Filho30
Estimated H-index: 30
(USP: University of São Paulo)
Estudo caso-controle conduzido para avaliar a associacao de exposicoes ocupacionais e câncer oral e orofaringe na Regiao Metropolitana de Sao Paulo. Inclui 325 casos e 468 controles, recrutados por frequencia de sexo e faixa etaria, entrevistados entre janeiro de 1999 e marco de 2002. A analise por ramos de atividade e ocupacoes foi restrita aos homens (266 casos, 362 controles) e os odds ratios (OR), calculados por regressao logistica nao-condicional, foram controlados por idade, tabagismo e co...
27 Citations Source Cite
Published on Jan 1, 2006in Cancer Detection and Prevention
Hristina Vlajinac19
Estimated H-index: 19
,
Jelena Marinkovic35
Estimated H-index: 35
+ 3 AuthorsSvetlana L. Stosic-Divjak1
Estimated H-index: 1
Abstract Background : In order to test some hypotheses of risk factors for oropharyngeal cancer (neoplasm of base of tongue, palate and tonsils) matched case–control study was conducted in Belgrade, Serbia and Montenegro, during the period 1998–2000. Methods : Study comprised 100 incidence cases with oropharyngeal cancer and 100 controls with some non-malignant diseases of head and neck. Results : According to multivariate analysis, ever smoking, interaction between smoking and alcohol consumpti...
18 Citations Source Cite
Published on May 12, 2005in Environmental Health Perspectives 8.05
Vincent Cogliano32
Estimated H-index: 32
,
Yann Grosse40
Estimated H-index: 40
+ 3 AuthorsFatiha El Ghissassi38
Estimated H-index: 38
An international, interdisciplinary working group of expert scientists met in June 2004 to develop IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans (IARC Monographs) on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol. Each IARC Monograph includes a critical review of the pertinent scientific literature and an evaluation of an agent’s potential to cause cancer in humans. After a thorough discussion of the epidemiologic, experimental, and other relevant...
197 Citations Source Cite
Published on Aug 1, 2003in Journal of Occupational and Environmental Medicine 1.59
Joseph B. Coble1
Estimated H-index: 1
,
Linda Morris Brown57
Estimated H-index: 57
+ 5 AuthorsJoseph F. Fraumeni132
Estimated H-index: 132
The work history information from a population-based case-control study conducted in Puerto Rico was analyzed using a job exposure matrix to investigate the relationship between occupational exposures and cancers of the oral cavity or pharynx. After adjustment for age, alcohol, smoking, and residence in a logistic model, the risk for cancer of the oral cavity, but not the pharynx, was significantly elevated among farm workers in the sugarcane industry (OR = 4.4, 95% CI = 1.4-13.6). An exposure-r...
26 Citations Source Cite
Published on Jul 1, 2002in Journal of Laryngology and Otology 1.26
Ana Escribano Uzcudun4
Estimated H-index: 4
,
Ignacio Rabanal Retolaza1
Estimated H-index: 1
+ 4 AuthorsJavier Gavilán Bouzas1
Estimated H-index: 1
The aim of this study was to determine risk factors for pharyngeal cancer and to propose 10 result-based preventive measures. It was a case-control study conducted in Madrid, Spain, with 232 consecutive patients diagnosed between January 1 1990 and December 31, 1995, sex- and age-matched with 232 control individuals with no oncological disease or history. By means of an interviewer-administered questionnaire, seven different epidemiological areas were surveyed, namely: (1) sociodemographic varia...
15 Citations Source Cite
Published on Jul 1, 2001in British Journal of Cancer 5.42
L Fernandez Garrote2
Estimated H-index: 2
,
Rolando Herrero91
Estimated H-index: 91
(IARC: International Agency for Research on Cancer)
+ 5 AuthorsSilvia Franceschi127
Estimated H-index: 127
(IARC: International Agency for Research on Cancer)
In terms of worldwide levels, Cuba has an intermediate incidence of cancer of the oral cavity and oro-pharynx. We studied 200 cases of cancer of the oral cavity and pharynx, of whom 57 women (median age = 64) and 200 hospital controls, frequency matched with cases by age and sex, in relation to smoking and drinking history, intake of 25 foods or food groups, indicators of oral hygiene and sexual activity, and history of sexually transmitted diseases. Odds ratios (OR) and 95% confidence intervals...
180 Citations Source Cite
Published on Jan 1, 2001
Robert E. Brackett35
Estimated H-index: 35
,
D. F. Splittstoesser1
Estimated H-index: 1
287 Citations Source Cite
Published on Jan 1, 2001in Cancer Epidemiology, Biomarkers & Prevention 5.06
Allan Hildesheim86
Estimated H-index: 86
,
Mustafa Dosemeci1
Estimated H-index: 1
+ 10 AuthorsPaul H. Levine45
Estimated H-index: 45
Our objective was to evaluate the link between occupational exposures to wood dust, formaldehyde, and solvents and the development of nasopharyngeal carcinoma (NPC). A case-control study was conducted among 375 newly diagnosed cases of NPC in Taipei, Taiwan, and 325 community controls matched to cases on sex, age, and geographical residence (99 and 87% response rates, respectively). Most cases (>90%) were diagnosed with WHO Types 2 or 3 (nonkeratinizing and undifferentiated carcinomas), whereas ...
120 Citations
Published on Dec 1, 2000in International Journal of Epidemiology 7.34
R. Warwick Armstrong4
Estimated H-index: 4
(UIUC: University of Illinois at Urbana–Champaign),
Peter B. Imrey18
Estimated H-index: 18
(UIUC: University of Illinois at Urbana–Champaign)
+ 3 AuthorsSham Sani6
Estimated H-index: 6
(UKM: National University of Malaysia)
Background During 1990-1992, 282 Chinese residents of Selangor and the Federal Territory, Malaysia with histologically confirmed nasopharyngeal carcinoma (NPC) were interviewed about occupational history, diet, alcohol consumption, and tobacco use, as were an equal number of Malaysian Chinese population controls, pair-matched to cases by age and sex. Methods Exposures to 20 kinds of workplace substances, solar and industrial heat, and cigarette smoke, were analysed by univariate and multivariate...
102 Citations Source Cite
Cited By5
Newest
Published on Jul 20, 2015in PLOS ONE 2.78
Montserrat Alonso-Sardón6
Estimated H-index: 6
(University of Salamanca),
Antonio-J. Chamorro1
Estimated H-index: 1
(University of Salamanca)
+ 5 AuthorsJosé Antonio Mirón-Canelo6
Estimated H-index: 6
(University of Salamanca)
Objective To perform a systematic review to analyze the association between occupational exposure to wood dust and cancer. Methods A systematic literature search of entries made in the MEDLINE-PubMed database between 1957 and 2013 was conducted to identify studies that had assessed the relationship between occupational exposure to wood dust and different types of cancer. A meta-analysis of selected case-control and cohort studies was subsequently performed. Results A total of 114 studies were id...
10 Citations Source Cite
Published on Jun 1, 2015in Carcinogenesis 4.00
Josiah Ochieng23
Estimated H-index: 23
(Meharry Medical College),
Gladys Nangami5
Estimated H-index: 5
(Meharry Medical College)
+ 31 AuthorsYunus A. Luqmani13
Estimated H-index: 13
(Kuniv: Kuwait University)
The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of lowdose environmental mixtures and carcinogens in the promotion of invasion and metastasis in specific tumors such as breast and prostate, the overarching theme is the role of low-dose carcinogens in the progression of cancer stem cells. It is becoming clearer t...
15 Citations Source Cite
Published on Jan 1, 2014
K. Namratha Pai1
Estimated H-index: 1
,
Asna Urooj1
Estimated H-index: 1
Cancer is a complex disease wherein mutations in protein-encoding genes lead to numerous tempo-spatial changes in cell physiology, ultimately leading to malignant tumors. Indian Population Based Cancer Registries documents incidences of cancers across the country and it was reported that highest Age Adjusted Rates was found in cancers of the tongue, hypopharynx and oesophagus which are head and neck cancers. They are amongst the commonest malignancies, accounting for approximately 20% of the can...
1 Citations
Published on Aug 1, 2012in Cancer management and research 2.24
Sie Sie Siew2
Estimated H-index: 2
,
Timo Kauppinen39
Estimated H-index: 39
+ 2 AuthorsEero Pukkala91
Estimated H-index: 91
Controversy exists over whether or not occupational inhalation exposure to wood dust and/or formaldehyde increases risk for respiratory cancers. The objective of this study was to examine the risk of nasal, nasopharyngeal, and lung cancer in relation to occupational exposure to wood dust and formaldehyde among Finnish men. The cohort of all Finnish men born between the years 1906 and 1945 and in employment during 1970 was followed up through the Finnish Cancer Registry for cases of cancers of th...
27 Citations Source Cite