Match!

Erythrocyte membrane trans-fatty acid index is positively associated with a 10-year CHD risk probability.

Published on May 1, 2013in British Journal of Nutrition3.319
· DOI :10.1017/S0007114513000196
Xiao-Ru Liu5
Estimated H-index: 5
(NCU: Nanchang University),
Zeyuan Deng33
Estimated H-index: 33
(NCU: Nanchang University)
+ 7 AuthorsWei-Feng Li1
Estimated H-index: 1
(NCU: Nanchang University)
Abstract
Industry-generated trans- fatty acids (TFA) are detrimental to risk of CHD, but ruminant-originated TFA have been reported as neutral or equivocal. Therefore, the total TFA amount should not be the only factor considered when measuring the effects of TFA. In the present study, we addressed whether a version of the TFA index that unifies the effects of different TFA isomers into one equation could be used to reflect CHD risk probability (RP). The present cross-sectional study involved 2713 individuals divided into four groups that represented different pathological severities and potential risks of CHD: acute coronary syndrome (ACS, n 581); chronic coronary artery disease (CCAD, n 631); high-risk population (HRP, n 659); healthy volunteers (HV, n 842). A 10-year CHD RP was calculated. Meanwhile, the equation of the TFA index was derived using five TFA isomers ( trans -16 : 1 n -7, trans -16 : 1 n -9, trans -18 : 1 n -7, trans -18 : 1 n -9 and trans -18 : 2 n -6 n -9), which were detected in the whole blood, serum and erythrocyte membranes of each subject. The TFA index and the 10-year CHD RP were compared by linear models. It was shown that only in the erythrocyte membrane, the TFA isomers were significantly different between the groups. In the ACS group, industry-generated TFA ( trans -16 : 1 n -9, trans -18 : 1 n -9 and trans -18 : 2 n -6 n -9) were the highest, whereas ruminant-originated TFA ( trans -16 : 1 n -7 and trans -18 : 1 n -7), which manifested an inverse relationship with CHD, were the lowest, and vice versa in the HV group. The TFA index decreased progressively from 7·12 to 5·06, 3·11 and 1·92 in the ACS, CCAD, HRP and HV groups, respectively. The erythrocyte membrane TFA index was positively associated with the 10-year CHD RP ( R 2 0·9981) and manifested a strong linear correlation, which might reflect the true pathological severity of CHD.
  • References (46)
  • Citations (12)
📖 Papers frequently viewed together
826 Citations
199423.05Circulation
313 Citations
1,166 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References46
Newest
To assess the relationships of lipoprotein mass concentrations to all-cause and coronary heart disease (CHD) mortality, we analyzed the prospective 53-year follow-up of 1,905 men measured for lipoprotein mass concentrations by analytic ultracentrifugation between 1954 and 1957. Cause of death was determined from medical records and death certificates before 1979 and from National Death Index death diagnoses thereafter. Of the 1,329 men (69.8%) who died through 2008, CHD was listed as a contribut...
16 CitationsSource
#1Vanessa Rungapamestry (UCD: University College Dublin)H-Index: 8
#2Jolene McMonagle (UCD: University College Dublin)H-Index: 8
Last. Helen M. Roche (UCD: University College Dublin)H-Index: 53
view all 12 authors...
cis-9, trans-11-Conjugated linoleic acid (c9 t11 CLA) exerts anti-diabetic effects by improving systemic insulin sensitivity and inflammation. Levels of CLA in beef can be increased by feeding cattle on pasture. This study aimed to explore the efficacy of a CLA-rich diet (0.6% w/w c9 t11 CLA), presented as beef enriched with CLA or beef supplemented with synthetic CLA (c9 t11 CLA), for 28 days on molecular biomarkers of the metabolic syndrome, and adipose, hepatic, and skeletal muscle proteome i...
8 CitationsSource
#1Massimo Bionaz (UIUC: University of Illinois at Urbana–Champaign)H-Index: 29
#2B. J. Thering (UIUC: University of Illinois at Urbana–Champaign)H-Index: 5
Last. Juan J Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 49
view all 3 authors...
Madin–Darby Bovine Kidney cells cultured with 150mM of Wy-14 643 (WY, PPARa agonist) or twelve long-chain fatty acids (LCFA; 16 : 0, 18 : 0, cis-9–18 : 1, trans-10–18 : 1, trans-11–18 : 1, 18 : 2n-6, 18 : 3n-3, cis-9, trans-11–18 : 2, trans-10, cis-12–18 : 2, 20 : 0, 20 : 5n-3 and 22 : 6n-3) were used to uncover PPAR-a target genes and determine the effects of LCFA on expression of thirty genes with key functions in lipid metabolism and inflammation. Among fifteen known PPAR-a targets in non-rum...
53 CitationsSource
#1Nathalie T. BendsenH-Index: 10
#2Stefan StenderH-Index: 49
Last. A. AstrupH-Index: 96
view all 10 authors...
Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16 week double-blind parallel intervention study with the objective to examine the effect of IP-TFA intake on biomarkers of inflammation, oxidative stress, and endothelial dysfunction. Fifty-two healthy overweight postm...
43 CitationsSource
Background: Dietary surveys indicate that New Zealanders have a low intake of trans-fatty acids (TFA) with little derived from industrial sources. This observational cross-sectional study in New Zealand patients with surgical coronary artery disease assesses the plasma levels of TFA and the association of TFA levels with clinical markers of vascular disease.Methods: 390 patients with severe coronary artery had fasting blood tests taken. Plasma levels of four TFA derived from hydrogenated vegetab...
16 CitationsSource
#1Brian Moyers (UCSF: University of California, San Francisco)H-Index: 6
#2Ramin Farzaneh-Far (UCSF: University of California, San Francisco)H-Index: 21
Last. Mary A. Whooley (UCSF: University of California, San Francisco)H-Index: 68
view all 6 authors...
Dietary intake of n-3 polyunsaturated fatty acids is associated with a lower incidence of cardiovascular events. Mechanisms underlying this association are poorly understood but may include beneficial effects on physical conditioning and vagal tone. We investigated the association of n-3 fatty acid levels to exercise parameters in 992 subjects with stable coronary artery disease. Cross-sectional associations of heart rate recovery time, treadmill exercise capacity, and exercise time with docosah...
22 CitationsSource
#1Nima Sanadgol (Zabol University)H-Index: 11
#2Ali Mostafaie (Kermanshah University of Medical Sciences)H-Index: 17
Last. Ali Bidmeshkipour (Razi University)H-Index: 8
view all 6 authors...
Abstract Objectives Elaidic acid, the predominant trans-fatty acid in industrially hydrogenated oils, exists on high levels in Iranian hydrogenated oils and margarines. This study was undertaken to investigate the effect of elaidic acid and its cis-counterpart oleic acid on expression of ICAM-1 and VCAM-1 on human bone marrow endothelial cells (HBMECs). Design and methods HBMEC were pre-treated with TNF-α or LPS for induction of the adhesion molecules expression, and then treated with elaidic ac...
19 CitationsSource
#1Rozenn N. Lemaitre (UW: University of Washington)H-Index: 61
#2Irena B. King (UNM: University of New Mexico)H-Index: 47
Last. David S. Siscovick (UW: University of Washington)H-Index: 125
view all 13 authors...
Little is known of the associations of endogenous fatty acids with sudden cardiac arrest (SCA). We investigated the associations of SCA with red blood cell membrane fatty acids that are end products of de novo fatty acid synthesis: myristic acid (14:0), palmitic acid (16:0), palmitoleic acid (16:1 n7), vaccenic acid (18:1 n7), stearic acid (18:0), oleic acid (18:1 n9) and a related fatty acid cis-7 hexadecenoic acid (16:1 n9). We used data from a population-based case-control study, where cases,...
38 CitationsSource
#1Renata Micha (Harvard University)H-Index: 40
#2Irena B. King (UNM: University of New Mexico)H-Index: 47
Last. Dariush Mozaffarian (Harvard University)H-Index: 120
view all 8 authors...
Background: The overall consumption of trans fatty acids (TFAs) increases the risk of coronary artery disease. However, multiple TFA isomers exist, each with potentially different health effects. Different food sources of these specific TFA isomers are not well established. Objective: Our objective was to determine the major independent food sources of specific TFA isomers. Design: We investigated relations of major potential food sources of TFAs, as assessed by serial food-frequency questionnai...
65 CitationsSource
Abstract Context.—Whether cell membrane fatty acid (FA) composition is a useful indicator of vascular disease is unclear. Objective.—To study variation of erythrocyte (RBC) membrane FA in samples f...
14 CitationsSource
Cited By12
Newest
#1Shelley M. Vanderhout (U of T: University of Toronto)H-Index: 2
#2Mary Aglipay (St. Michael's Hospital)H-Index: 2
Last. Jonathon L. MaguireH-Index: 9
view all 9 authors...
BACKGROUND: The majority of children in North America consume cow-milk daily. Children aged >2 y are recommended to consume reduced-fat (0.1-2%) cow-milk to lower the risk of obesity. OBJECTIVES: To evaluate the relation between cow-milk fat consumption and adiposity in children aged 1-18 y. METHODS: Embase (Excerpta Medica Database), CINAHL (Cumulative Index to Nursing and Allied Health Literature), MEDLINE, Scopus, and Cochrane Library databases from inception to August 2019 were used. The sea...
4 CitationsSource
#1Carina A. Valenzuela (University of Southampton)H-Index: 1
#2Ella J. Baker (University of Southampton)H-Index: 3
Last. Philip C. Calder (University of Southampton)H-Index: 105
view all 4 authors...
Abstract Endothelial dysfunction is a pro-inflammatory state characterized by chronic activation of the endothelium, which leads to atherosclerosis and cardiovascular disease (CVD). Intake of trans fatty acids (TFAs) is associated with an increased risk of CVD. This risk is usually associated with industrial TFAs (iTFAs) rather than ruminant TFAs (rTFAs); however it is not clear how specific TFA isomers differ in their biological activity and mechanisms of action with regard to inflammation. Her...
Source
#1Heather C. Kuiper (CDC: Centers for Disease Control and Prevention)H-Index: 1
#2Na Wei (CDC: Centers for Disease Control and Prevention)H-Index: 1
Last. Hubert W. Vesper (CDC: Centers for Disease Control and Prevention)H-Index: 29
view all 4 authors...
Abstract Trans-fatty acids (TFA) are geometric isomers of naturally occurring cis-fatty acids. High dietary TFA intake has been associated with risk factors for cardiovascular disease. However, little is known about TFA levels in humans. To address this data need, we developed and validated a new isotope dilution-gas chromatography-negative chemical ionization-mass spectrometry (ID-GC-NCI-MS) method for quantitation of 27 fatty acids (FA) including 4 major TFA in human plasma, serum, and red blo...
1 CitationsSource
#1P. Vahmani (AAFC: Agriculture and Agri-Food Canada)H-Index: 11
#2William J. Meadus (AAFC: Agriculture and Agri-Food Canada)H-Index: 7
Last. E R DuganMichael (AAFC: Agriculture and Agri-Food Canada)H-Index: 27
view all 5 authors...
The present study compared the lipogenic/cholesterolgenic effects of t6-, t9- (positive control), t10-, t11-, t13-, t14-, t15-18:1, cis(c)9-18:1 (cis control) or bovine serum albumin (BSA; negative control) in liver cells (HepG2). Fatty acids (100 μM) were complexed to BSA, and cells were incubated for 24 h. Two wells of cells were cultured per treatment per experiment, and the experiment was repeated three times (n = 6). The fatty acid treatments had no effect on cell viability compared to BSA....
7 CitationsSource
#1Clemens von Schacky (LMU: Ludwig Maximilian University of Munich)H-Index: 28
#2Adrian PassowH-Index: 1
Last. R Kiefl (LMU: Ludwig Maximilian University of Munich)H-Index: 12
view all 3 authors...
Purpose High, but not low levels of trans-fatty acids (TFA) in erythrocytes are associated with increased mortality. Current erythrocyte TFA levels in Europe are not known.
7 CitationsSource
#1P. Vahmani (AAFC: Agriculture and Agri-Food Canada)H-Index: 11
#2William J. Meadus (AAFC: Agriculture and Agri-Food Canada)H-Index: 7
Last. E R DuganMichael (AAFC: Agriculture and Agri-Food Canada)H-Index: 27
view all 8 authors...
Beef fat is a natural source of trans (t) fatty acids, and is typically enriched with either t10-18:1 or t11-18:1. Little is known about the bioactivity of individual t-18:1 isomers, and the present study compared the effects of t9-18:1, cis (c)9-18:1 and trans (t)-18:1 fractions isolated from beef fat enriched with either t10-18:1 (HT10) or t11-18:1 (HT11). All 18:1 isomers resulted in reduced human liver (HepG2) cell viability relative to control. Both c9-18:1 and HT11were the least toxic, t9-...
2 CitationsSource
#1Marcus E. Kleber (Heidelberg University)H-Index: 51
#2Graciela Delgado (Heidelberg University)H-Index: 20
Last. Clemens von Schacky (LMU: Ludwig Maximilian University of Munich)H-Index: 28
view all 5 authors...
Background Saturated fatty acids are thought to be harmful by increasing the risk for cardiovascular events. Objective We examined the associations of erythrocyte saturated fatty acids with total and cardiovascular mortality in patients referred for coronary angiography. Methods Red blood cell saturated fatty acid (RBC SFA) proportions were measured by gas chromatography at baseline in 3259 participants of the Ludwigshafen Risk and Cardiovascular Health study. Associations of saturated fatty aci...
32 CitationsSource
#1Marcus E. Kleber (Heidelberg University)H-Index: 51
#2Graciela Delgado (Heidelberg University)H-Index: 20
Last. Clemens von Schacky (LMU: Ludwig Maximilian University of Munich)H-Index: 28
view all 5 authors...
Aims Trans -fatty acids (TFAs) are generated by the food industry and also occur naturally in trace amounts in dairy products. For the latter, beneficial health effects have been claimed, while there are numerous reports about TFA of industrial origin being hazardous to human health. Therefore, we aimed to investigate the association of TFA with mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Methods and results The fatty acid composition of erythrocyte membranes was ...
53 CitationsSource
#1Farid MenaaH-Index: 10
#2Bouzid MenaaH-Index: 13
Last. Abder MenaaH-Index: 7
view all 4 authors...
Abstract Trans fatty acids (TFAs) are produced either from biohydrogenation or industrial hydrogenation. Industrial TFAs are deleterious and might lead to various pathologies, such as cardiovascular diseases (CVDs) and cancers. The molecular mechanisms mediated by TFAs and their association to diseases remain unclear. Thereby, although a number of studies strongly showed that TFAs lower HDL-cholesterol and raise LDL-cholesterol, one can argue that LDL-cholesterol is not the main factor that lead...
Source
#1Farid MenaaH-Index: 10
#2Bouzid MenaaH-Index: 13
Last. Abder MenaaH-Index: 7
view all 4 authors...
Source