Inflammatory bowel disease aggregation in Utah kindreds

The observed heritability of inflammatory bowel disease (IBD) is incompletely explained by known genetic risk factors. Kindred-specific genetic variants that cause IBD may be a source of “missing heritability.” Given that they have been previously difficult to identify, we sought to identify high-risk IBD kindreds. We used a large population-based database—the Utah Population Database (UPDB)—which contains genealogical and healthcare data to...