Mass spectrometric analysis of 2′-deoxyribonucleoside and 2′-deoxyribonucleotide adducts with aldehydes derived from lipid peroxidation
Volume: 12, Issue: 22, Pages: 1665 - 1672
Published: Nov 30, 1998
Abstract
An important emerging issue in chemical carcinogenesis is the role that products of endogenous metabolism play in formation of covalently modified DNA. One example is the formation of alpha, beta-unsaturated aldehydes as a result of endogenous and drug-stimulated lipid peroxidation. Malondialdehyde (MDA), crotonaldehyde (CR), 2-hexenal (HX), and 4-hydroxy-2-nonenal (HNE) react covalently with 2'-deoxyguanosine (dG) and 2'-deoxyadenosine (dA)...
Paper Details
Title
Mass spectrometric analysis of 2′-deoxyribonucleoside and 2′-deoxyribonucleotide adducts with aldehydes derived from lipid peroxidation
Published Date
Nov 30, 1998
Volume
12
Issue
22
Pages
1665 - 1672
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