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Magnetic Resonance Imaging of the Phase Separation in Mixed Preparations of Moisturizing Cream and Steroid Ointment after Centrifugation

Published on Jan 1, 2015in Chemical & Pharmaceutical Bulletin1.405
· DOI :10.1248/cpb.c15-00088
Yoshinori Onuki15
Estimated H-index: 15
(Hoshi University),
Chiaki Funatani2
Estimated H-index: 2
(Hoshi University)
+ 5 AuthorsKozo Takayama47
Estimated H-index: 47
(Hoshi University)
Abstract
: A mixed preparation consisting of a water-in-oil emulsion-type moisturizing cream and a steroid ointment is frequently prescribed for the treatment of atopic dermatitis. We have investigated the compatibility of moisturizing creams and ointments because there are concerns regarding the physical stability of these mixed preparations. The key technology used in this study was magnetic resonance imaging (MRI). A commercial moisturizing cream and white petrolatum or clobetasone butyrate (CLB) ointment samples were mixed in a weight ratio of 1 : 1. A centrifugation test protocol (20000×g for 3 min) was implemented to accelerate the destabilization processes in the samples. After centrifugation, the mixed preparations separated into three distinct layers (upper, middle, and lower), while no phase separation was observed using moisturizing cream alone. The phase separation was monitored using chemical shift selective images of water and oil and quantitative T2 maps. In addition, MR and near-infrared spectroscopy were employed for component analysis of each phase-separated layer. Collectively, it was confirmed that the lower layer contained water, oils, and organic solvent, while the upper and middle layers were composed solely of oils. Furthermore, this study investigated the distribution of CLB in the phase-separated samples and showed that a heterogeneous distribution existed. From our results, it was confirmed that the mixed preparation became unstable because of the incompatibility of the moisturizing cream and ointment.
  • References (1)
  • Citations (8)
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References1
Newest
#1Anuj Shukla (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 6
#2Martin Janich (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 12
Last. Reinhard H.H. Neubert (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 38
view all 6 authors...
Purpose. Stable oil/water (o/w) microemulsions are very effective vehicle systems for dermal administration of drugs having no or low skin penetration. These systems, consisting of oils, a blend of a high and a low HLB surfactant, and a hydrophilic phase (propylene glycol/water), were developed using pharmaceutically acceptable components.
30 CitationsSource
Cited By8
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Background: The clobetasol propionate cream formulations (CLB Cr ) belong to the "strongest" group, and are used widely. In addition, those formulations are often used as a mixture with moisturizer. Recently, we evaluated pharmaceutical properties of the CLB Cr using near infrared (NIR) spectroscopy, and characteristic NIR spectra depending on the formulation were observed. In the present study, we attempted to evaluate the more diverse pharmaceutical properties of CLB Cr , including the stabili...
Source
BACKGROUND: In order to manufacture pharmaceutical products, real-time monitoring in the manufacturing process is necessary, but large equipment cost is required to achieve it. OBJECTIVE: The aim of this research is to use ultra-violet-visible spectroscopy along with chemometrics procedure to simultaneously carry out quantitative analysis of indomethacin (IMC) and benzoic acid (BA) in the gel during pharmaceutical manufacturing process. METHODS: The gel preparations contained 0.1-1.5% IMC, 0.015...
Source
#1Yoshihisa Yamamoto (Teikyo Heisei University)H-Index: 5
#2Akane Hanai (Teikyo Heisei University)H-Index: 1
Last. Tatsuo KoideH-Index: 11
view all 10 authors...
Abstract Betamethasone butyrate propionate ointment (BBPO) is mainly used for adult patients in dermatology and is often prescribed as a mixture containing a base or moisturizing cream for various reasons. However, in the case of a moisturizing cream, since this formulation is composed of various ingredients, a physical change is expected to occur by mixing it with an ointment. Therefore, in the present study, the physical stability of a mixture of four BBPO formulations and heparinoid oily crea...
2 CitationsSource
#1Emma S. ThompsonH-Index: 2
#2Pieter Saveyn (P&G: Procter & Gamble)H-Index: 9
Last. Melanie M. BrittonH-Index: 16
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Abstract In complex colloidal systems, particle-poor regions can develop within particle-rich phases during sedimentation or creaming. These particle-poor regions are overlooked by 1D profiles, which are typically used to assess particle distributions in a sample. Alternative methods to visualise and quantify these regions are required to better understand phase separation, which is the focus of this paper. Magnetic resonance imaging has been used to monitor the development of compositional hete...
7 CitationsSource
#1Yoshinori Onuki (University of Toyama)H-Index: 15
#2Chiaki Funatani (Hoshi University)H-Index: 2
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 7 authors...
: A moisturizing cream mixed with a steroid ointment is frequently prescribed to patients suffering from atopic dermatitis. However, there is a concern that the mixing operation causes destabilization. The present study was performed to investigate the stability of such preparations closely using magnetic resonance imaging (MRI). As sample preparations, five commercial moisturizing creams that are popular in Japan were mixed with an ointment base, a white petrolatum, at a volume ratio of 1 : 1. ...
Source
#1Yoshinori Onuki (University of Toyama)H-Index: 15
#2Masamitsu Yokokawa (Hoshi University)H-Index: 1
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 8 authors...
: A menthol-diphenhydramine cream is prepared in hospital pharmacies and then prescribed to patients for the treatment of pruritus associated with chronic kidney disease. The purpose of this study is to design a stable formulation without any concern about phase separation during its clinical use on patients. As a preventive measure against phase separation, various surfactants and thickeners were incorporated into the creams. The test creams were stored at 40°C, and then their phase separation ...
1 CitationsSource
#1Yoshinori Onuki (University of Toyama)H-Index: 15
#2Chihiro Kida (Hoshi University)H-Index: 3
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 5 authors...
We have recently established a novel method to evaluate the emulsion stability of pharmaceutical skin cream. The key technology of the method is magnetic resonance imaging (MRI). The purpose of this study was to verify the usefulness of the method in the cosmetic industry.Milky lotion-type emulsions were employed as test samples. We note that the test samples were prepared by taking account of commercial milky lotions. After the sample preparation, a centrifugation treatment (5000 g for up to 12...
6 CitationsSource
#1Sylwester Mazurek (UWr: University of Wrocław)H-Index: 13
#2Roman Szostak (UWr: University of Wrocław)H-Index: 25
Abstract A method for quantitative determination of ibuprofen (IBU), naproxen (NAP), methyl salicylate (MES) and menthol (MNT) in commercial topical gels and ointments using partial least squares (PLS) models based on FT-Raman spectra is described. The calculated relative standard errors of prediction (RSEP) were found to be in the range of 2.1–3.2% for the calibration and validation data sets. Two commercial topical gels containing 5.0% of IBU and 10% of NAP (w/w), as well as one ointment conta...
7 CitationsSource
#1Shuji Kitagawa (Kobe Pharmaceutical University)H-Index: 17
#2Reiko Yutani (Kobe Pharmaceutical University)H-Index: 5
Last. Reiko Teraoka (Kobe Pharmaceutical University)H-Index: 13
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Most steroidal ointments contain propylene glycol (PG) and surfactants, which improve the solubility of corticosteroids in white petrolatum. Surfactants aid the uniform dispersal of PG within white petrolatum. Since the surfactants used in generic ointments are usually different from those used in brand name ointments, we investigated the effects of surfactants on the rheological properties of three brand name ointments and six equivalent generic ointments. We detected marked differences in hard...
5 CitationsSource