Failure of B-cell differentiation in mice lacking the transcription factor EBF
Abstract
Early B-cell factor (EBF) is a cell type-specific transcription factor that is expressed at all antigen-independent stages of B-lymphocyte differentiation and participates in the regulation of the mb-1 gene. Here we show, by targeted gene disruption in mice, that EBF is necessary for the generation of immunoglobulin-expressing B cells. EBF-deficient mice lack B cells that have rearranged their immunoglobulin D and JH gene segments, but contain...
Paper Details
Title
Failure of B-cell differentiation in mice lacking the transcription factor EBF
Published Date
Jul 1, 1995
Journal
Volume
376
Issue
6537
Pages
263 - 267
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