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Effects of endothelial nitric oxide synthase tagSNPs haplotypes on nitrite levels in black subjects.

Published on Jan 1, 2013in Nitric Oxide3.37
· DOI :10.1016/j.niox.2012.10.002
Ingrid F. Metzger14
Estimated H-index: 14
(USP: University of São Paulo),
Marcelo R. Luizon14
Estimated H-index: 14
(USP: University of São Paulo)
+ 2 AuthorsJose E. Tanus-Santos34
Estimated H-index: 34
(USP: University of São Paulo)
Abstract
Abstract Haplotypes formed by clinically relevant polymorphisms in the endothelial nitric oxide synthase ( eNOS ) gene have been associated with variations in endogenous nitric oxide (NO) formation in white and black subjects. We examined whether further genetic variation and haplotypes of the eNOS gene, represented by the rs3918188, rs743506 and rs7830 tagSNPs (polymorphisms that represent the information of neighboring SNPs in linkage disequilibrium) affect endogenous NO formation in 181 healthy black subjects. We measured whole blood nitrite concentration as a marker of endogenous NO formation for each subject. We found that the heterozygotes CA for the tagSNP rs7830 ( P  = 0.0278, OR = 0.4839, CI 95% 0.2567–0.9121), as well as the haplotype “C–G–A” ( P  = 0.0068), were more common in subjects with low circulating whole blood nitrite concentrations compared with subjects with high circulating whole blood nitrite concentrations, although the genotype finding is not significant after correction for multiple comparisons. These findings suggest that these tagSNPs of the eNOS gene and haplotypes are associated with low levels of nitric oxide production in blacks, and could be used as a marker of cardiovascular risk.
  • References (60)
  • Citations (9)
References60
Newest
#1Marcelo R. Luizon (USP: University of São Paulo)H-Index: 14
#2Ingrid F. Metzger (USP: University of São Paulo)H-Index: 14
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 34
view all 4 authors...
#1Helena Manso (IGC: Instituto Gulbenkian de Ciência)H-Index: 8
#2Tiago Krug (IGC: Instituto Gulbenkian de Ciência)H-Index: 8
Last.Astrid M. Vicente (IGC: Instituto Gulbenkian de Ciência)H-Index: 33
view all 8 authors...
#1Toby Johnson (QMUL: Queen Mary University of London)H-Index: 97
#2Tom R. Gaunt (Medical Research Council)H-Index: 46
Last.Neil Poulter (Imperial College London)H-Index: 78
view all 104 authors...
Cited By9
Newest
#1Marcelo R. Luizon (UFMG: Universidade Federal de Minas Gerais)H-Index: 3
#2Daniela A. Pereira (UFMG: Universidade Federal de Minas Gerais)H-Index: 1
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 34
view all 3 authors...
#1Marcelo R. Luizon (UFMG: Universidade Federal de Minas Gerais)H-Index: 3
#2Daniela A. Pereira (UFMG: Universidade Federal de Minas Gerais)H-Index: 1
Last.Valéria Cristina Sandrim (UNESP: Sao Paulo State University)H-Index: 8
view all 3 authors...
#1Gustavo H. Oliveira-Paula (USP: University of São Paulo)H-Index: 9
#2Riccardo Lacchini (USP: University of São Paulo)H-Index: 16
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 25
view all 3 authors...
#1Gustavo H. Oliveira-Paula (USP: University of São Paulo)H-Index: 9
#2Riccardo Lacchini (State University of Campinas)H-Index: 16
Last.Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 25
view all 7 authors...
#1Naiel Azzam (University of Haifa)H-Index: 3
#2Barak Zafrir (Technion – Israel Institute of Technology)H-Index: 10
Last.Offer Amir (BIU: Bar-Ilan University)H-Index: 6
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View next paperEndothelial nitric oxide synthase gene haplotypes affect nitrite levels in black subjects.