Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia
Abstract
Cancer cells rely on angiogenesis to fulfil their need for oxygen and nutrients; hence, agents targeting angiogenic pathways and mediators have been investigated as potential cancer drugs. Although this strategy has demonstrated delayed tumour progression--leading to progression-free survival and overall survival benefits compared with standard therapy--in some patients, the results are more modest than predicted. A significant number of...
Paper Details
Title
Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia
Published Date
Apr 24, 2012
Volume
9
Issue
7
Pages
378 - 390
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