Seroprevalence of HIV in the US Household Population Aged 18–49 Years: The National Health and Nutrition Examination Surveys, 1999–2006.

Published on Jan 1, 2010in Journal of Acquired Immune Deficiency Syndromes3.863
· DOI :10.1097/QAI.0b013e3181b3a8e3
Geraldine M. McQuillan35
Estimated H-index: 35
Deanna Kruszon-Moran25
Estimated H-index: 25
+ 1 AuthorsJane W Feldman1
Estimated H-index: 1
Objective: To monitor trends in HIV seroprevalence in the United States, HIV testing was included in the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2006. Methods: From 1999 to 2006, 11,928 participants aged 18-49 years were tested for HIV antibody. Prevalence estimates were weighted to account for oversampling and nonresponse. Results: There were 67 HIV antibody-reactive individuals for a seroprevalence of 0.5% [95% confidence interval (CI) 0.3-0.6]. In the only age subgroup directly comparable between surveys (18-39 years), HIV seroprevalence remained constant from NHANES III (1988-1994) to NHANES 1999-2002 and 2003-2006. In NHANES 1999-2006, non-Hispanic blacks had significantly higher HIV seroprevalence (2.0%, 95% CI 1.5-2.7) compared with individuals in all other race/ethnic groups combined. Seroprevalence was also higher in each race/ethnic group among men who have sex with men (9.4% 95% CI 5.0-17.1), among persons who had detectable antibody to herpes simplex type-two (1.9% 95% CI 1.4-2.8), among those who had 50 or more lifetime sex partners (3.4%, 95% CI 1.7-6.7), and among those who never married (0.8%, 95% CI 0.5-1.3). Conclusions: In this household-based population, seroprevalence did not significantly change from NHANES III to NHANES 1999-2006. Non-Hispanic blacks had significantly higher prevalence of infection compared with other race/ethnic groups. Male-to-male sex and the presence of HSV-2 antibody were the strongest predictors of HIV infection.
  • References (12)
  • Citations (20)
📖 Papers frequently viewed together
11 Authors (H. Irene Hall, ..., Robert S. Janssen)
1,172 Citations
3 Citations
20122.78PLOS ONE
10 Authors (Luc Béhanzin, ..., Michel Alary)
7 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1H. Irene Hall (CDC: Centers for Disease Control and Prevention)H-Index: 45
#2Ruiguang Song (CDC: Centers for Disease Control and Prevention)H-Index: 20
Last. Robert S. Janssen (CDC: Centers for Disease Control and Prevention)H-Index: 52
view all 11 authors...
1,172 CitationsSource
#1Philippe Van de Perre (University of Montpellier)H-Index: 44
#2Michel Segondy (University of Montpellier)H-Index: 1
Last. Nicolas Nagot (University of Montpellier)H-Index: 21
view all 8 authors...
Recent proof-of-concept randomised controlled trials have shown a causal relation between herpes simplex virus (HSV) type 2 infection and HIV-1 replication in co-infected individuals. We explore the mechanisms that may operate to enhance reciprocal viral replication. Direct interactions could involve HIV-1-related immune deficiency, disruption of mucosal barrier by HSV infection/reactivation, HSV-induced mucosal cell recruitment, transactivation of HIV-1 replication by HSV proteins, and immune m...
140 CitationsSource
#1Judith A. Cook (UIC: University of Illinois at Chicago)H-Index: 37
#2Jane K. Burke-Miller (UIC: University of Illinois at Chicago)H-Index: 17
Last. Dennis D. Grey (UIC: University of Illinois at Chicago)H-Index: 25
view all 13 authors...
Recent research suggests that cocaine may directly affect the pathobiology of HIV by causing immune alterations in different lymphocytes such as helper T cells (CD4), suppressor/cytotoxic T cells (CD8), and natural killer (NK) cells.1 Studies show that cocaine interferes with the body’s ability to defend against infection by inhibiting the effector functions of neutrophils and macrophages, and by suppressing cytokine production, decreasing operation of important immune responses.2 Cocaine also e...
157 CitationsSource
#1Cathy J. Reback (UCLA: University of California, Los Angeles)H-Index: 28
#2Jonathan B. KamienH-Index: 7
Last. Leslie AmassH-Index: 23
view all 3 authors...
During January and February 2003, 20 non-treatment seeking homeless, substance-using MSM accessing community-based prevention services in West Hollywood, California were assessed to characterize demographics, addiction and psychiatric severity using structured and semi-structured clinical interviews, and high-risk drug and sexual behavior. Participants averaged 37 years old, were mostly Caucasian/white (65%) and most identified as bisexual (58%) or gay (37%). Self-reported HIV seroprevalence was...
23 CitationsSource
To examine trends in HIV prevalence in the US household population, serum or urine samples from 2 National Health and Nutrition Examinations Surveys (NHANES) (1988 -- 1994 and 1999-2002), were tested for HIV antibody. In the 1999 to 2002 survey, data on risk behaviors, CD4 T lymphocytes, and antiretroviral therapy (ART) were also available. In the 1988 to 1994 survey, there were 59 positive individuals of 11,203 tested. In NHANES 1999 to 2002, there were 32 positive individuals of 5926 tested. T...
49 CitationsSource
#1Clyde B. McCoyH-Index: 35
#2Shenghan Lai (UM: University of Miami)H-Index: 51
Last. Wei Zhao (UM: University of Miami)H-Index: 6
view all 5 authors...
Abstract Purpose Previous studies have examined the practices of injecting drugs or smoking crack cocaine as high-risk, but independent, factors for HIV transmission. To explore the independent and dual risks of injection practices and crack smoking, this study examined HIV seroprevalence rates among distinct drug user groups, based on patterns of daily administration. Methods A sample of 3555 drug users and neighborhood controls in urban Miami, FL and rural Belle Glade and Immokalee, FL were pa...
70 CitationsSource
#1Marjorie J. Robertson (UCSF: University of California, San Francisco)H-Index: 23
#2Richard A.F. Clark (UCSF: University of California, San Francisco)H-Index: 69
Last. Andrew R. Moss (UCSF: University of California, San Francisco)H-Index: 59
view all 7 authors...
Objectives. We report HIV seroprevalence and risk factors for urban indigent adults.Methods. A total of 2508 adults from shelters, meal programs, and low-cost hotels received interviews, blood tests, and tuberculosis screening.Results. Seroprevalence was 10.5% overall, 29.6% for men reporting sex with men (MSM), 7.7% for non-MSM injection drug users (IDUs), and 5.0% for residual non-MSM/non-IDUs. Risk factors were identified for MSM (sex trade among Whites, non-White race, recent receptive anal ...
194 CitationsSource
#1Frank J. van Lenthe (EUR: Erasmus University Rotterdam)H-Index: 44
#2Evelien GeversH-Index: 2
Last. Johan P. Mackenbach (EUR: Erasmus University Rotterdam)H-Index: 54
view all 5 authors...
PURPOSE: To quantify the contribution of material and behavioral factors to educational differences in the incidence of acute myocardial infarction (AMI), taking into account their interrelationship. METHODS: Self-reported information about educational level, behavioral factors (alcohol, smoking, physical inactivity, and obesity), and material factors (housing conditions, crowding, employment status, financial problems, and an income proxy) was obtained from 45 to 74 year old responders to the b...
64 CitationsSource
#1Stephen F. Morin (UCSF: University of California, San Francisco)H-Index: 41
#2Sohini SenguptaH-Index: 1
Last. James S. KahnH-Index: 69
view all 7 authors...
Objectives.The objectives of this study were to assess racial/ethnic trends in surveillance data in four states—California, New York, Florida and Texas, identify structural barriers to and facilitators of access to HIV pharmaceuticals by individuals in Medicaid and the AIDS Drug Assistance Program (ADAP), and identify treatment education and outreach efforts responding to the needs of ethnic minority HIV patients.Methods.State surveillance and claims data were used to assess trends by race/ethni...
44 CitationsSource
To provide an estimate of the seroprevalence of human immunodeficiency virus (HIV) in a representative sample of the U.S. household population, serum samples from participants in the third National Health and Nutrition Examination Survey (NHANES III) were tested for HIV antibody. The testing was performed anonymously on 5,430 individuals 18-59 years old from phase 1 of NHANES III conducted from 1988 to 1991. Twenty-nine individuals were HIV positive. The total weighted prevalence was 0.39%. The ...
63 CitationsSource
Cited By20
#1Peter A. Leone (UNC: University of North Carolina at Chapel Hill)H-Index: 32
Genital herpes is the most prevalent cause of genital ulcer disease in the world and is commonly encountered in the HIV primary care setting. While most herpes simplex virus (HSV) infections are asymptomatic, HIV-infected individuals are more likely to present with atypical and severe manifestations of this common infection. This chapter will discuss the natural history, evaluation, management, and prevention of genital HSV infections as well as discuss useful counseling strategies for providers...
#1Candice K. Kwan (NYU: New York University)H-Index: 1
#2Charles E. Rose (CDC: Centers for Disease Control and Prevention)H-Index: 28
Last. Catlainn Sionean (CDC: Centers for Disease Control and Prevention)H-Index: 17
view all 5 authors...
Testing for human immunodeficiency virus (HIV) is the key first step in HIV treatment and prevention. In 2006, the Centers for Disease Control and Prevention (CDC) recommended annual HIV testing for people at high risk for HIV infection. We evaluated HIV testing among men with high-risk heterosexual (HRH) contact and sexually active men who have sex with men (MSM) before and after the CDC recommendations.We used data from the National Survey of Family Growth, 2002 and 2006-2010, to assess propor...
7 CitationsSource
#1Dheeraj KumarH-Index: 59
#2Abhi HumarH-Index: 38
Last. B. KiberdH-Index: 1
view all 4 authors...
Donors at increased risk of transmitting viral infections are a potential source of transplantable organs. Studies demonstrate that organs from increased risk donors (IRDs) are associated with excellent outcomes. However, considerable variation in practice likely exists.We performed a cross-country survey of Canadian Organ Transplant centers to determine organ utilization practices from IRDs.Of 40 surveys sent to transplant programs across Canada, 24 (60%) were returned. Of those, 60.9% (15/24) ...
4 CitationsSource
#1Karen McKinnon (Columbia University)H-Index: 22
#2Katherine S. Elkington (Columbia University)H-Index: 20
Last. Milton L. Wainberg (Columbia University)H-Index: 16
view all 6 authors...
Serious mental illness (SMI) and HIV are overlapping health conditions in the U.S. When an individual has either condition, the increased disease burden of having the other condition is likely to worsen health outcomes for reasons that are obvious, yet poorly understood. Despite a quarter-century of research and development of prevention interventions and treatment services, a glaring lack of data means that planning to reduce the devastating health effects of these co-occurring conditions is oc...
#1Lesley S. Park (Stanford University)H-Index: 13
#2Raúl U. Hernández-Ramírez (Yale University)H-Index: 13
Last. Robert Dubrow (Yale University)H-Index: 47
view all 5 authors...
The burden of cancer among persons living with HIV/AIDS (PLWHA) is substantial and increasing. We assessed the prevalence of modifiable cancer risk factors among adult PLWHA in Western high-income countries since 2000.Meta-analysis.We searched PubMed to identify articles published in 2011-2013 reporting prevalence of smoking, alcohol consumption, overweight/obesity, and infection with human papillomavirus (HPV), hepatitis C virus (HCV) and hepatitis B virus (HBV) among PLWHA. We conducted random...
54 CitationsSource
#1Ya-Lin A. Huang (CDC: Centers for Disease Control and Prevention)H-Index: 2
#2Emma L. FrazierH-Index: 13
Last. Jacek SkarbinskiH-Index: 31
view all 9 authors...
The effects of HIV infection on national labor-force participation have not been rigorously evaluated. Using data from the Medical Monitoring Project and the National Health Interview Survey, we present nationally representative estimates of the receipt of disability benefits by adults living with HIV receiving care compared with the general US adult population. We found that in 2009, adults living with HIV were nine times more likely than adults in the general population to receive disability b...
3 CitationsSource
#1Amy Lansky (CDC: Centers for Disease Control and Prevention)H-Index: 36
#2Teresa Finlayson (CDC: Centers for Disease Control and Prevention)H-Index: 15
Last. Nicole Crepaz (CDC: Centers for Disease Control and Prevention)H-Index: 35
view all 10 authors...
Background: Injection drug use provides an efficient mechanism for transmitting bloodborne viruses, including human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Effective targeting of resources for prevention of HIV and HCV infection among persons who inject drugs (PWID) is based on knowledge of the population size and disparity in disease burden among PWID. This study estimated the number of PWID in the United States to calculate rates of HIV and HCV infection. Methods: We conducte...
96 CitationsSource
#1Matthew E. Levy (GW: George Washington University)H-Index: 4
#2Leo Wilton (Binghamton University)H-Index: 21
Last. Manya Magnus (GW: George Washington University)H-Index: 26
view all 9 authors...
Structural-level factors have contributed to the substantial disproportionate rates of HIV among Black men who have sex with men (BMSM) in the United States. Despite insufficient HIV testing patterns, however, there is a void in research investigating the relationship between structural factors and access to HIV testing and prevention services among BMSM. Building on previous scholarly work and incorporating a dynamic social systems conceptual framework, we conducted a comprehensive review of th...
85 CitationsSource
#1Alicia K. MatthewsH-Index: 29
#2Maria VargasH-Index: 4
Last. Andrea C. KingH-Index: 34
view all 5 authors...
Purpose: To identify barriers and motivators to smoking cessation among HIVpositive African American men-who-have-sex with men (MSM) who smoke. Procedures: A convenience sample of smokers was recruited for this study using a range of outreach approaches. Focus groups (N = 4) were conducted that examined: quit experiences, barriers to and motivators of cessation, cultural beliefs, and community norms. Established qualitative methods were used to conduct and analyze the focus groups. Findings: Par...