Ancient Whole Genome Enrichment Using Baits Built from Modern DNA
Abstract
We report metrics from complete genome capture of nuclear DNA from extinct mammoths using biotinylated RNAs transcribed from an Asian elephant DNA extract. Enrichment of the nuclear genome ranged from 1.06- to 18.65-fold, to an apparent maximum threshold of ∼80% on-target. This projects an order of magnitude less costly complete genome sequencing from long-dead organisms, even when a reference genome is unavailable for bait...
Paper Details
Title
Ancient Whole Genome Enrichment Using Baits Built from Modern DNA
Published Date
Feb 13, 2014
Volume
31
Issue
5
Pages
1292 - 1294
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