Inhibitors of the Interactions between HIV‐1 IN and the Cofactor LEDGF/p75
Abstract
The replication cycle of human immunodeficiency virus type 1 (HIV-1) is a complex multistep process that depends on both viral and host cell factors. The nuclear protein lens epithelium-derived growth factor (LEDGF/p75) is a multidomain protein, present in host cells, which plays an important role in the integration process. LEDGF/p75 not only binds HIV-1 integrase (IN) at its IN binding domain (IBD) but also contains several motifs that...
Paper Details
Title
Inhibitors of the Interactions between HIV‐1 IN and the Cofactor LEDGF/p75
Published Date
Apr 19, 2011
Journal
Volume
6
Issue
7
Pages
1184 - 1191
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