Double trouble? Progranulin mutation and C9ORF72 repeat expansion in a case of primary non-fluent aphasia

Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of disorders characterized by progressive atrophy of the frontal and temporal lobes of the brain. FTLD can be classified into behavioral variant frontotemporal dementia (bvFTD) and primary progressive aphasia (PPA): bvFTD consists of a progressive deterioration of personality with behavioral alterations and executive dysfunction, while PPA is characterized by language...