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Induction of Heme Oxygenase‐1 mRNA and Protein in Neocortex and Cerebral Vessels in Alzheimer's Disease

Published on Nov 23, 2002in Journal of Neurochemistry4.87
· DOI :10.1046/j.1471-4159.1995.65031399.x
Daniel R. D. Premkumar15
Estimated H-index: 15
,
Mark A. Smith119
Estimated H-index: 119
(Case Western Reserve University)
+ 6 AuthorsRajesh N. Kalaria55
Estimated H-index: 55
(Case Western Reserve University)
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Abstract
Previous studies demonstrated the specific association of heme oxygenase (HO)-1 protein to the neurofibrillary pathology of Alzheimer's disease (AD). In this study, we used reverse transcription-polymerase chain reaction methods to show the increased expression of HO-1 but not HO-2 mRNA transcripts in cerebral cortex and cerebral vessels from subjects with AD compared with age-matched non-AD controls. Neither the HO-1 nor the HO-2 mRNA level was altered in the cerebellum, a brain region usually spared from the pathological alterations of AD. There was no clear evidence that the expression of HO-1 in these tissues was related to postmortem interval, cause of death, or the age of the subjects studied. Using immunoblotting methods, we further showed that HO-1 protein content was increased in neocortical and vascular samples from AD subjects compared with controls. Our findings suggest the specific induction of HO-1 mRNA and protein in the cerebral cortex and cerebral vessels but not HO-2 mRNA or protein in association with the pathological lesions of the disease. Key Words : Alzheimer's disease-Amyloid β-protein-Antioxidants-Cerebral vessels-Heat-shock proteins-Heme oxygenase-I -Heme oxygenase-2-Stress proteins. J. Neurochem. 65, 1399-1402 (1995).
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Published on Aug 22, 2019in Archives of Toxicology5.74
Miriama Simunkova1
Estimated H-index: 1
,
Saleh H. Alwasel23
Estimated H-index: 23
(KSU: King Saud University)
+ 4 AuthorsMarian Valko1
Estimated H-index: 1
(KSU: King Saud University)
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder, characterized by the formation, aggregation and accumulation of amyloid beta, perturbed metal (copper, iron and zinc) homeostasis, metal-induced oxidative stress, neuroinflammation, aberrant activity of acetylcholinesterase (AChE) and other pathologies. The aim of this review is to discuss the current therapies based on the “combination-drugs-multitargets” strategy to target multiple pathologies to block the progression of ...
Published on 2019in Antioxidants
Naufal Kushairi , Chia-Wei Phan9
Estimated H-index: 9
+ 2 AuthorsMurali Naidu17
Estimated H-index: 17
Oxidative stress and inflammation in neuron-glia system are key factors in the pathogenesis of neurodegenerative diseases. As synthetic drugs may cause side effects, natural products have gained recognition for the prevention or management of diseases. In this study, hot water (HE-HWA) and ethanolic (HE-ETH) extracts of the basidiocarps of Hericium erinaceus mushroom were investigated for their neuroprotective and anti-inflammatory activities against hydrogen peroxide (H2O2)-induced neurotoxicit...
Published on Aug 1, 2019in Talanta4.92
Shengyi Gong2
Estimated H-index: 2
(CCNU: Central China Normal University),
Jiaxin Hong (CCNU: Central China Normal University)+ 1 AuthorsGuoqiang Feng18
Estimated H-index: 18
(CCNU: Central China Normal University)
Abstract Near-infrared (NIR) fluorescent probes with a large Stokes shift are very practical tools for bioimaging applications. Carbon monoxide (CO) is a key gaseous signal molecule and its imaging in living systems has attracted great attention in recent years. In this work, a very easy-to-get NIR fluorescent probe with a remarkable large pseudo-Stokes shift (238 nm) for detection of CO was reported. This probe was found to show a rapid NIR fluorescent turn-on response for CO with high selectiv...
Published on Dec 1, 2018in Phytomedicine4.18
Xin Wang (NU: Nanjing University), Ya-Nan Gai (CAS: Chinese Academy of Sciences)+ 1 AuthorsLi-Li Huang (NU: Nanjing University)
Abstract Background Neuroinflammation plays an important role in many neurodegenerative conditions such as Alzheimer's disease (AD) and Parkinson disease (PD). Andalucin (ADL), a sesquiterpene lactone from Artemisia lannta , has been reported to exhibit NO inhibition in vitro . However, the effect of ADL on microglia-mediated neuroinflammation has not been investigated. Purpose This study was designed to determine the anti-neuroinflammatory effect of ADL against LPS-activated BV2 microglial cell...
Published on Oct 1, 2018in Talanta4.92
Song-Jiao Li6
Estimated H-index: 6
(XTU: Xiangtan University),
Dong-Ye Zhou4
Estimated H-index: 4
(XTU: Xiangtan University)
+ 5 AuthorsChun-Yan Li15
Estimated H-index: 15
(XTU: Xiangtan University)
Abstract Carbon monoxide is a critical gasotransmitter in the body and related with mitochondrial respiration. To date, various fluorescent probes for CO have been well proposed, but two main problems remain. One is that most of the probes are not mitochondria-targeting, even if the probes claim to be able to detect CO in living cells. The other is that the probes for CO display excitation and emission within the ultraviolet or visible range, which hinders their applications in vivo. Herein, a h...
Pragati Priyadarshinee4
Estimated H-index: 4
,
Manoj Kumar Jha6
Estimated H-index: 6
+ 2 AuthorsSachin S. Kamble8
Estimated H-index: 8
SMEs play a very vital role in each market by significantly contributing to each country's gross domestic product (GDP) and labour market. Therefore, proposing new strategies or developing new systems that can help SMEs become more efficient and productive is not only beneficial for SMEs but also for the economy of a country as a whole. The decision about cloud computing adoption is crucial for every manufacturing firm. However, the selection on an appropriate system may prove difficult, especia...
Published on Jan 1, 2017in BioMed Research International2.20
Ulfuara Shefa3
Estimated H-index: 3
(Kyung Hee University),
Seung Geun Yeo20
Estimated H-index: 20
(Kyung Hee University)
+ 4 AuthorsYoungbuhm Huh20
Estimated H-index: 20
(Kyung Hee University)
To date, three main gasotransmitters, that is, hydrogen sulfide (H2S), carbon monoxide (CO), and nitric oxide (NO), have been discovered to play major bodily physiological roles. These gasotransmitters have multiple functional roles in the body including physiologic and pathologic functions with respect to the cellular or tissue quantities of these gases. Gasotransmitters were originally known to have only detrimental and noxious effects in the body but that notion has much changed with years; v...
Published on Dec 1, 2016in Advanced Materials25.81
Yanglei Xu4
Estimated H-index: 4
(Beihang University),
Xin Sui4
Estimated H-index: 4
(Beihang University)
+ 2 AuthorsLongcheng Gao11
Estimated H-index: 11
(Beihang University)
Published on Nov 15, 2016in Analytical Chemistry6.35
Yong Li8
Estimated H-index: 8
,
Xu Wang21
Estimated H-index: 21
+ 5 AuthorsBo Tang54
Estimated H-index: 54
Carbon monoxide (CO), a crucial gas message molecule, plays an important role in the regulation of physiological and pathological process. Hypoxia-induced CO is involved in modulating various cellular activities, including signal transduction, proliferation, and apoptosis. However, tracking CO fluctuation in the hypoxic cells is still a challenge due to lack of straightforward, visualized, and noninvasive tools. In this work, based on metal palladium-catalyzed reaction, we present the rational d...