Integrated regulation of motor-driven organelle transport by scaffolding proteins
Abstract
Intracellular trafficking pathways, including endocytosis, autophagy, and secretion, rely on directed organelle transport driven by the opposing microtubule motor proteins kinesin and dynein. Precise spatial and temporal targeting of vesicles and organelles requires the integrated regulation of these opposing motors, which are often bound simultaneously to the same cargo. Recent progress demonstrates that organelle-associated scaffolding...
Paper Details
Title
Integrated regulation of motor-driven organelle transport by scaffolding proteins
Published Date
Oct 1, 2014
Journal
Volume
24
Issue
10
Pages
564 - 574
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Notes
History