Effect of the organotin compound triethyltin on Ca2+ handling in human prostate cancer cells
Abstract
The effects of triethyltin on Ca2+ mobilization in human PC3 prostate cancer cells have been explored. Triethyltin increased [Ca2+]i at concentrations larger than 3 microM with an EC50 of 30 microM. Within 5 min, the [Ca2+]i signal was composed of a gradual rise and a sustained phase. The [Ca2+]i signal was reduced by half by removing extracellular Ca2+. The triethyltin-induced [Ca2+]i increases were inhibited by 40% by 10 microM nifedipine,...
Paper Details
Title
Effect of the organotin compound triethyltin on Ca2+ handling in human prostate cancer cells
Published Date
Feb 1, 2002
Journal
Volume
70
Issue
11
Pages
1337 - 1345
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