Histochemical studies in the zone of ischemia following middle cerebral artery occlusion in cats

✓ Representative enzymes in brain were studied by histochemical techniques at intervals varying between 6 hours and 8 weeks after permanent middle cerebral artery occlusion in 18 cats. Unequivocal enzyme changes did not develop until 12 hours after occlusion, and no specific enzyme system was demonstrated to fail prior to others. That the ischemia of the first 6 hours is reversible in the cat was further substantiated by histological studies in...