Original paper

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

Volume: 46, Issue: 2, Pages: 136 - 143
Published: Jan 12, 2014
Abstract
Type 2 diabetes affects over 300 million people, causing severe complications and premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic islet dysfunction is central in type 2 diabetes pathogenesis, and understanding islet genome regulation could therefore provide valuable mechanistic insights. We have now mapped and examined the function of human islet cis-regulatory networks. We identify genomic sequences that...
Paper Details
Title
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants
Published Date
Jan 12, 2014
Volume
46
Issue
2
Pages
136 - 143
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