Match!

Adiposity as compared with physical activity in predicting mortality among women.

Published on Dec 23, 2004in The New England Journal of Medicine70.67
· DOI :10.1056/NEJMoa042135
Frank B. Hu205
Estimated H-index: 205
(Harvard University),
Barry M. Popkin323
Estimated H-index: 323
(Harvard University)
+ 3 AuthorsJoAnn E. Manson235
Estimated H-index: 235
(Harvard University)
Abstract
Background Whether higher levels of physical activity can counteract the elevated risk of death associated with adiposity is controversial. Methods We examined the associations of the body-mass index and physical activity with death among 116,564 women who, in 1976, were 30 to 55 years of age and free of known cardiovascular disease and cancer. Results During 24 years of follow-up, 10,282 deaths occurred — 2370 from cardiovascular disease, 5223 from cancer, and 2689 from other causes. Mortality rates increased monotonically with higher body-mass-index values among women who had never smoked (P for trend <0.001). In combined analyses of all participants, adiposity predicted a higher risk of death regardless of the level of physical activity. Higher levels of physical activity appeared to be beneficial at all levels of adiposity but did not eliminate the higher risk of death associated with obesity. As compared with women who were lean (i.e., they had a body-mass index lower than 25) and active (they spent ...
  • References (30)
  • Citations (708)
📖 Papers frequently viewed together
2,707 Citations
319 Citations
199651.27JAMA
1,444 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References30
Newest
#1June Stevens (UNC: University of North Carolina at Chapel Hill)H-Index: 66
The Cancer Prevention Study II indicated that obesity might be associated with a smaller increase in the relative rate of mortality in African-Americans compared with whites. The absolute death rate in obese whites, however, was not higher than in obese African-Americans. Avoidance of obesity remains sound advice.
65 CitationsSource
#1Umed A. AjaniH-Index: 40
#2Paulo A. LotufoH-Index: 64
Last. JoAnn E. MansonH-Index: 235
view all 8 authors...
Abstract Purpose To assess the relationship between body mass index and mortality in a population homogeneous in educational attainment and socioeconomic status. Methods We analyzed the association between body mass index (BMI) and both all-cause and cause-specific mortality among 85,078 men aged 40 to 84 years from the Physicians' Health Study enrollment cohort. Results During 5 years of follow-up, we documented 2856 deaths (including 1212 due to cardiovascular diseases and 891 due to cancer). ...
133 CitationsSource
#1Timothy R. Wessel (UF: University of Florida)H-Index: 14
Last. C. Noel Bairey MerzH-Index: 71
view all 12 authors...
ContextIndividual contributions of obesity and physical fitness (physical activity and functional capacity) to risk of coronary heart disease in women remain unclear.ObjectiveTo investigate the relationships of measures of obesity (body mass index [BMI], waist circumference, waist-hip ratio, and waist-height ratio) and physical fitness (self-reported Duke Activity Status Index [DASI] and Postmenopausal Estrogen-Progestin Intervention questionnaire [PEPI-Q] scores) with coronary artery disease (C...
313 CitationsSource
#1Peter T. Katzmarzyk (Queen's University)H-Index: 85
#2JanssenIan (Queen's University)H-Index: 73
Last. Chris I. ArdernH-Index: 27
view all 3 authors...
Summary The purpose of this report is to review the evidence that physical inactivity and excess adiposity are related to an increased risk of all-cause mortality, and to better identify the independent contributions of each to all-cause mortality rates. A variance-based method of meta-analysis was used to summarize the relationships from available studies. The summary relative risk of all-cause mortality for physical activity from the 55 analyses (31 studies) that included an index of adiposity...
256 CitationsSource
#1Mary Ellen Simpson (CDC: Centers for Disease Control and Prevention)H-Index: 1
#2Mary K. Serdula (CDC: Centers for Disease Control and Prevention)H-Index: 70
Last. Karin A. Mack (CDC: Centers for Disease Control and Prevention)H-Index: 31
view all 7 authors...
Abstract Objective To examine trends in walking among adults in 31 states. Methods Trends by sociodemographic strata were analyzed from respondents who participated in the Behavioral Risk Factor Surveillance System (BRFSS). Results The prevalence of walking among men increased 3.8% (95% confidence interval [CI]=2.4–5.2), from 26.2% (95% CI=25.1–25.3) in 1987 to 30.1% (95% CI=29.4–30.8) in 2000. In women, walking increased 6.6% (95% CI=5.4–7.8), from 40.4% (95% CI=–39.4–41.1) to 46.9% (95% CI=46....
197 CitationsSource
#1June StevensH-Index: 66
#2Jianwen CaiH-Index: 44
Last. Ratna P. Thomas (UNC: University of North Carolina at Chapel Hill)H-Index: 9
view all 4 authors...
319 CitationsSource
#1Katherine M. Flegal (CDC: Centers for Disease Control and Prevention)H-Index: 89
#2Margaret D. CarrollH-Index: 54
Last. Clifford L. JohnsonH-Index: 41
view all 4 authors...
ContextThe prevalence of obesity and overweight increased in the United States between 1978 and 1991. More recent reports have suggested continued increases but are based on self-reported data.ObjectiveTo examine trends and prevalences of overweight (body mass index [BMI] ≥25) and obesity (BMI ≥30), using measured height and weight data.Design, Setting, and ParticipantsSurvey of 4115 adult men and women conducted in 1999 and 2000 as part of the National Health and Nutrition Examination Survey (N...
5,568 CitationsSource
#1Frank B. Hu (Harvard University)H-Index: 205
#2JoAnn E. Manson (Harvard University)H-Index: 235
Last. Barry M. Popkin (Harvard University)H-Index: 323
view all 7 authors...
Background Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown. Methods We followed 84,941 female nurses from 1980 to 1996; these women were free of diagnosed cardiovascular disease, diabetes, and cancer at base line. Information about their diet and lifestyle was updated periodically. A low-risk group was defined according to a combination of five variables: a body-mass index (the w...
2,099 CitationsSource
BLAIR, S. N., Y. CHENG, and J. S. HOLDER. Is physical activity or physical fitness more important in defining health benefits? Med. Sci. Sports Exerc., Vol. 33, No. 6, Suppl., 2001, pp. S379 ‐S399. Purpose: We addressed three questions: 1) Is there a dose-response relation between physical activity and health? 2) Is there a dose-response relation between cardiorespiratory fitness and health? 3) If both activity and fitness have a dose-response relation to health, is it possible to determine whic...
782 CitationsSource
51 CitationsSource
Cited By708
Newest
#1Xiaochen Zhang (OSU: Ohio State University)H-Index: 5
#2Rebecca E. Cash (Harvard University)
Last. Electra D. Paskett (OSU: Ohio State University)H-Index: 56
view all 5 authors...
Purpose We sought to determine whether the association between physical activity and 10-year cardiovascular disease (CVD) risk varies among normal weight, overweight, and obese adults in a nationally-representative sample of the United States. Methods Data were from the National Health and Nutrition Examination Survey 2007–2016. A subset of 22,476 participants aged 30–64 years was included with no CVD history. Physical activity level was self-reported and stratified into sedentary (0 min/week), ...
Source
#2Maria Grazia Vaccaro (Magna Græcia University)H-Index: 2
Last. AntonioAversaH-Index: 40
view all 10 authors...
Ageing is associated with declines in cognitive functions and physical fitness (PF). Physical exercise training and physical activity (PA) have been shown to have positive effects on cognitive functions and brain plasticity. This study aims to establish a practical equation for evaluating cognitive functions using PF parameters in healthy older adults. One-hundred and two older subjects were physically and clinically evaluated. Participants performed the Short Physical Performance Battery (SPPB)...
Source
#1Guohua LiH-Index: 3
#2Jia LiH-Index: 7
Last. Feng GaoH-Index: 92
view all 3 authors...
Source
Source
Objectives: To determine the prevalence of cardiovascular disease (CVD) risk factors in current field-based athletes. Design: Meta-analysis. Methods: This review was conducted and reported in accordance with PRISMA and pre-registered with PROSPERO. Articles were retrieved via online database search engines, with no date or language restriction. Studies investigating current field-based athletes (>18years) for CVD risk factors according to the European Society of Cardiology and American Heart Ass...
Source
#1Marte Karoline Råberg Kjøllesdal (University of Oslo)H-Index: 7
#2Inger Ariansen (FHI: Norwegian Institute of Public Health)H-Index: 12
Last. Øyvind Næss (University of Oslo)H-Index: 24
view all 3 authors...
The time between early adulthood and midlife is important for obesity development. There is paucity of studies using objectively measured body mass index (BMI) at both time points with full range of midlife cardiovascular risk factors. We aimed to investigate the risk of cardiovascular disease (CVD) mortality associated with different levels of objectively measured change in body weight from early adulthood to midlife, and to assess whether risk is primarily explained by midlife cardiovascular r...
Source
#1Tracey G. Simon (Harvard University)H-Index: 10
#2Mi Na Kim (Harvard University)
Last. Andrew T. ChanH-Index: 80
view all 14 authors...
Abstract Background & Aims Obesity in adulthood has been associated with increased risk of liver-related mortality. Whether higher levels of physical activity counteract the excess risk conferred by obesity remains unknown. We simultaneously evaluated the long-term impact of physical activity and adiposity on liver-related mortality, within two nationwide populations. Methods We conducted a prospective cohort study of 77,238 women and 48,026 men, with detailed, validated assessments of weekly ph...
Source
In the U.S., 54.8% of non-Hispanic Black women are obese, a rate that is 1.4 times greater than in White women. The drivers of this racial disparity are not yet clearly understood. We sought to disentangle race, household poverty, neighborhood racial composition, and neighborhood poverty to better understand the racial disparity in obesity among women. We used data from the 1999-2004 National Health and Nutrition Examination Survey and the 2000 U.S. Census to examine the role of individual race,...
Source
#1Britta Wilms (University of Lübeck)H-Index: 2
#2Rahel Keppler (HSG: University of St. Gallen)H-Index: 1
Last. Bernd Schultes (HSG: University of St. Gallen)H-Index: 41
view all 6 authors...
Background Even subjects with severe obesity show a wide range of metabolic health states, with some showing marked alterations in glucose and lipid metabolism whereas others do not. In severely obese women, we could recently show that the degree of cardiorespiratory fitness is, independently of body mass and age, associated with several markers of glucose and lipid metabolism. Aims In our retrospective study on a clinical data set, we questioned whether such an association also exists in severe...
Source
#1S Wernhart (TUM: Technische Universität München)
#2Martin Halle (TUM: Technische Universität München)H-Index: 38
AbstractPurpose: Cardiorespiratory fitness (CRF) is a predictor of lower mortality in patients with coronary artery disease (CAD) and cancer patients. Whether cancer survivors with preserved ejecti...
Source