Protective effect of umbelliferone on high-fructose diet-induced insulin resistance and oxidative stress in rats

The present study was designed to investigate the effect of umbelliferone (UMB) on insulin resistance (IR) and oxidative stress in rats fed a high fructose diet (HFD). Male Wistar rats received a daily diet containing either 60% fructose or 60% starch. They were administered with the UMB at three different doses (10, 20 and 40 mg/kg, p.o) from the 16th day. At the end of 60 days, HFD rats exhibited significant increases in plasma glucose and...