Conversion of Channelrhodopsin into a Light-Gated Chloride Channel

Science56.90
Volume: 344, Issue: 6182, Pages: 409 - 412
Published: Apr 25, 2014
Abstract
The field of optogenetics uses channelrhodopsins (ChRs) for light-induced neuronal activation. However, optimized tools for cellular inhibition at moderate light levels are lacking. We found that replacement of E90 in the central gate of ChR with positively charged residues produces chloride-conducting ChRs (ChloCs) with only negligible cation conductance. Molecular dynamics modeling unveiled that a high-affinity Cl(-)-binding site had been...
Paper Details
Title
Conversion of Channelrhodopsin into a Light-Gated Chloride Channel
Published Date
Apr 25, 2014
Journal
Volume
344
Issue
6182
Pages
409 - 412
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