The role of 5-HT1A receptors in phencyclidine (PCP)-induced novel object recognition (NOR) deficit in rats

Atypical antipsychotic drugs (APDs), many of which are direct or indirect serotonin (5-HT)1A agonists, and tandospirone, a 5-HT1A partial agonist, have been reported to improve cognition in schizophrenia. We tested the effect of 5-HT1A agonism, alone, and in combination with other psychotropic agents, including the atypical APD, lurasidone, in reversing the deficit in novel object recognition (NOR) induced by subchronic treatment with the...