Dendritic and mitochondrial changes during glutamate excitotoxicity
Abstract
Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS) and is normally stored intracellularly. However, in instances of CNS injury or disease, increased concentrations of extracellular glutamate can result in the over-activation of ionotropic glutamate receptors and trigger neuronal cell death (termed excitotoxicity). Two early hallmarks of such neuronal toxicity are mitochondrial dysfunction...
Paper Details
Title
Dendritic and mitochondrial changes during glutamate excitotoxicity
Published Date
Dec 1, 2007
Journal
Volume
53
Issue
8
Pages
891 - 898
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