Formulation and evaluation of matrix type mucoadhesive tablets aimed at treating oral aphtha

Nonsteroidal anti-inflammatory drugs (NSAIDs) are administered for pain relief from oral mucositis. However, the systemic administration of NSAIDs is limited due to the side effects of thrombocytopenia.To avoid systemic side effects, a matrix type mucoadhesive tablet as a topical application preparation to treat oral aphtha was developed.A mixture of hard fat with a low irritant property and mucoadhesive polymers was used as the matrix base, and...