Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
Abstract
Efficient intracellular delivery of proteins is needed to fully realize the potential of protein therapeutics. Current methods of protein delivery commonly suffer from low tolerance for serum, poor endosomal escape and limited in vivo efficacy. Here we report that common cationic lipid nucleic acid transfection reagents can potently deliver proteins that are fused to negatively supercharged proteins, that contain natural anionic domains or that...
Paper Details
Title
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
Published Date
Oct 30, 2014
Journal
Volume
33
Issue
1
Pages
73 - 80
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