Mice with reduced NMDA receptor expression: more consistent with autism than schizophrenia?

Volume: 11, Issue: 6, Pages: 740 - 750
Published: Aug 1, 2012
Abstract
Reduced NMDA-receptor (NMDAR) function has been implicated in the pathophysiology of neuropsychiatric disease, most strongly in schizophrenia but also recently in autism spectrum disorders (ASD). To determine the direct contribution of NMDAR dysfunction to disease phenotypes, a mouse model with constitutively reduced expression of the obligatory NR1 subunit has been developed and extensively investigated. Adult NR1neo−/− mice show multiple...
Paper Details
Title
Mice with reduced NMDA receptor expression: more consistent with autism than schizophrenia?
Published Date
Aug 1, 2012
Volume
11
Issue
6
Pages
740 - 750
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