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THE TRANSFER IN HUMANS OF DELAYED SKIN SENSITIVITY TO STREPTOCOCCAL M SUBSTANCE AND TO TUBERCULIN WITH DISRUPTED LEUCOCYTES

Published on Feb 1, 1955in Journal of Clinical Investigation12.282
· DOI :10.1172/JCI103075
H. Sherwood Lawrence1
Estimated H-index: 1
Abstract
  • References (27)
  • Citations (301)
References27
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#1John H. Vaughan (NewYork–Presbyterian Hospital)H-Index: 3
#2Elvin A. Kabat (Columbia University)H-Index: 65
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#1W. S. Jeter (UI: University of Iowa)H-Index: 3
#2Mary M. Tremaine (UI: University of Iowa)H-Index: 4
Last. Paul M. Seebohm (UI: University of Iowa)H-Index: 7
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SummaryPassive transfer of delayed cutaneous hypersensitivity to 274-dinitro-chlorobenzene in guinea pigs has been accomplished with extracts of peritoneal exudative leucocytes disrupted by sonic vibration. Crude extracts of cells treated and subsequently centrifuged were effective as transfer media. Sedimented material was essentially ineffective.
61 CitationsSource
#1Susanna HarrisH-Index: 8
#2T. N. HarrisH-Index: 22
Last. Miriam B. FarberH-Index: 10
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Summary Following the injection of dysentery bacilli, and other antigens, into the hind foot pad of rabbits, the popliteal (regional) lymph nodes were excised. The lymph node cells were teased free, washed and sedimented by centrifugation. These cells were then injected intravenously into normal rabbits. Antibody to the antigen injected into the donor animals appeared in the sera of the recipients on the first day after transfer, rose in titer on the second and third day and began to decline on ...
67 Citations
The capacity of rabbit anti-egg albumin sera to sensitize human skin has been studied. It has been shown that passive transfer by these sera is completely unrelated to the egg albumin-anti-egg albumin system, as demonstrated by a failure of passive transfer by some antisera containing ample anti-egg albumin and persistence of passive transfer in other antisera from which all anti-egg albumin had been removed by precipitation with homologous antigen. Three preparations of non-precipitating anti-e...
22 CitationsSource
Abstract Heparin and treburon, a synthetic heparin-like polysaccharide, inhibit pancreatic ribonuclease and ribonuclease activity in rat kidney and liver. Pancreatic desoxyribonuclease is inhibited to a lesser extent. The inhibition appears to be a competitive one between the acid polysaccharide and RNA or DNA. Benzimidazole greatly increased the initial reaction rate of pancreatic ribonuclease but had no effect on pancreatic desoxyribonuclease. The possible relationship of heparin inhibition of...
48 CitationsSource
62 CitationsSource
STUDIES in various countries agree that approximately two thirds of patients with sarcoidosis fail to react to second-strength tuberculin — 0.005 mg. of Purified Protein Derivative (PPD) or 1.0 mg. of Old Tuberculin (OT).1 2 3 The failure to react is not merely the result of absence of exposure to tuberculous infection, since patients with sarcoidosis proved unable to develop and maintain tuberculin sensitivity in normal fashion after BCG vaccination.2 , 3 This diminished reactivity to tuberculi...
55 CitationsSource
Type-specific M antigen was extracted by heating type 1 group A streptococci at pH 2 in a boiling water bath. The protein was then purified by digestion with a preparation of crystalline ribonuclease which was free of proteolytic activity. It was further purified by fractional precipitation with (NH4)2SO4. Elementary chemical analysis of the preparation thus obtained showed an absence of phosphorus and a sulfur content of 2.46 per cent. In the ultraviolet the maximum absorption was at a wave len...
82 CitationsSource
1. The immunological properties of two contrasting types of human antisera, each containing a high titer of diphtheria antitoxin, have been investigated. 2. Sera which contain only non-precipitating antitoxin exhibit most of the properties of atopic reagin-containing sera. This type of antitoxin is capable of sensitizing normal human skin to toxin or toxoid and remains for many weeks in the injected area. It exhibits no Danysz effect, does not fix complement unless very large amounts of serum ar...
31 CitationsSource
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#2Hanyu Qian (UF: University of Florida)
Last. Li Tan
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The current quality control methods relying mainly on chromogenic reaction can hardly ensure the quality and safety of the biochemical drug with complex chemical composition. Therefore, a chromatographic fingerprint method was developed for the quality evaluation of a multi-component biochemical drug, Transfer Factor Injection. HPLC-fingerprint was carried out on a C18 column (250 x 4.6 mm, 5 mum) with a mobile phase composed of 0.1% Trifluoroacetic acid-water and 0.085% Trifluoroacetic acid-ace...
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#1Andrea Diana (University of Cagliari)H-Index: 11
Last. Maria Dolores Setzu (University of Cagliari)H-Index: 11
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Within neurodegenerative syndromes, Parkinson’s disease (PD) is typically associated with its locomotor defects, sleep disturbances and related dopaminergic (DA) neuron loss. The fruit fly, Drosophila melanogaster (D. melanogaster), with leucine-rich repeat kinase 2 mutants (LRRK2) loss-of-function in the WD40 domain, provides mechanistic insights into corresponding human behaviour, possibly disclosing some physiopathologic features of PD in both genetic and sporadic forms. Moreover, several dat...
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#1Moisés Armides Franco-Molina (Universidad Autónoma de Nuevo León)H-Index: 12
#2Silvia Elena Santana-Krímskaya (Universidad Autónoma de Nuevo León)H-Index: 1
Last. Cristina Rodríguez-Padilla (Universidad Autónoma de Nuevo León)H-Index: 22
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ABSTRACTIMMUNEPOTENT CRP is a dialyzable leukocyte extract obtained from bovine spleen with immunomodulatory and antitumour properties; therefore, when administrated as an adjuvant therapy for cancer patients, it has increased their survival and quality of life. The bioavailability of any orally administered compound can be reduced due to gastrointestinal enzymes. In this study, we evaluated if IMMUNEPOTENT CRP is resistant to the treatment with different enzymes (proteases, nucleases, polysacch...
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#1Beatriz Eugenia Fuentes-Castro (IPN: Instituto Politécnico Nacional)H-Index: 2
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Last. Federico Martínez-Gómez (IPN: Instituto Politécnico Nacional)H-Index: 6
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Dialyzable leukocyte extracts (DLEs) contain molecules smaller than 10 kDa with biological activity in receptor organisms. Primarily, they participate in the regulation of the Th1 immune response, which is essential for the control of several intracellular infections, such as toxoplasmosis. This disease is associated with congenital infection, encephalitis or systemic infections in immunocompromised individuals. The clinical course of this infection fundamentally depends on a well-regulated immu...
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Abstract It is evident that standard chemotherapy agents may have an impact on both tumor and host immune system. Paclitaxel (PTX), a very potent anticancer drug from a taxane family, has achieved prominence in clinical oncology for its efficacy against a wide range of tumors including breast cancer. However, significant toxicity, such as myelosuppression, limit the effectiveness of Paclitaxel-based treatment regimens. Immodin (IM) is low molecular dialysate fraction of homogenate made from huma...
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#1Yifeng Miao (SJTU: Shanghai Jiao Tong University)H-Index: 4
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This work describes the use of a transfer factor, a low molecular protein that can transfer cell mediated immunity from donor to recipient, and CpG, a clinically relevant toll-like receptor agonist, for treating glioma. Transfer factor and CpG were assembled onto gold nanoparticles via layer-by-layer assembly. The modified nanoparticles (i.e. particles assembled with transfer factor and CpG) were characterized by size, zeta potential, and loading. An in vivo tumor study revealed that the nanopar...
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#1Emilio Medina-Rivero (IPN: Instituto Politécnico Nacional)H-Index: 11
#2Luis Vallejo-Castillo (IPN: Instituto Politécnico Nacional)H-Index: 4
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Transferon, a biotherapeutic agent that has been used for the past 2 decades for diseases with an inflammatory component, has been approved by regulatory authorities in Mexico (COFEPRIS) for the treatment of patients with herpes infection. The active pharmaceutical ingredient (API) of Transferon is based on polydispersion of peptides that have been extracted from lysed human leukocytes by a dialysis process and a subsequent ultrafiltration step to select molecules below 10 kDa. To physicochemica...
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#1Atanas Arnaudov (Plovdiv University "Paisii Hilendarski")H-Index: 5
#2Zhivka Kostova (Plovdiv University "Paisii Hilendarski")H-Index: 3
Dialysable leukocyte extracts (DLE) are complexes consisting of a large number of low-molecular-weight substances. These extracts have immunomodulatory properties, which are mainly attributed to small peptides commonly referred to as ‘transfer factor’. This review focuses on the characteristics of DLE with transfer factor activity, together with the methods for their preparation and purification. The opportunities for applying the extracts for immunotherapy purposes against various diseases in h...
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