Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels.
Abstract
Insulin secretion from β-cells of the pancreatic islets of Langerhans is triggered by Ca2+ influx through voltage-dependent Ca2+ channels. Electrophysiological and molecular studies indicate that β-cells express several subtypes of these channels. This review discusses their roles in regulating insulin secretion, focusing on recent studies using β-cells, exogenous expression systems, and Ca2+ channel knockout mice. These investigations reveal...
Paper Details
Title
Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels.
Published Date
Jul 15, 2004
Volume
200
Issue
2
Pages
57 - 66
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